Ferrocenyl imidazoliny palladium compound, its preparation method and its uses in catalytic synthesis of coupling product

Abstract

The invention discloses a ferrocenyl imidazoline palladacycle complexe, the preparation method and its application in catalizing coupling product. The general formula of compound is in the right. The method comprises: carrying out reaction with ferrocenyl imidic acid methyl ester hydrochlorate and vicinal diamine, getting ferrocenyl imidazoline compound through post treatment; carrying out reaction with mentioned compound above with palladium lithium halides and NaOAc in organic solvent while being stirred at room temperature, and getting final product. The catalytic synthesis of coupling product with siad compound comprises following steps: dissloving catalyst, aryl boracic acid, alkali and halogenated aromatic compound in organic solvent, heating for reaction, cooling for extraction, purifying and getting coupling product. The invention is characterized by high catalytic property, environmental- friendly, insenstive to aor and water, good thermal stability of non-phosphine ligand, easy processing route, temperate reaction condition, and high specificity.

Description

technical field [0001] The invention belongs to the technical field of catalysts, synthesis and its application in organic synthesis, and relates to a cyclopalladium compound, its preparation and its application in catalytically synthesizing coupling products. Background technique [0002] Coupling products, especially biaryl hydrocarbons, are important organic chemicals with a wide range of applications. Synthesis, with the development of my country's industry and economy, the demand for such compounds in related industries is increasing. [0003] The classic synthesis of biaryl hydrocarbon derivatives is commonly used by the Ullmann method. This method has poor versatility, many synthetic steps, uncertain chemical selectivity, and harsh reaction conditions. Aromatic hydrocarbon derivatives, in this type of reaction, generally use palladium inorganic salt plus ligand as the catalytic system, the catalytic effect of palladium is better among many transition metal elements, t...

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Problems solved by technology

[0003] The classic synthesis of biaryl hydrocarbon derivatives is commonly used by the Ullmann method. This method has poor versatility, many synthetic steps, uncertain chemical selectivity, and harsh reaction conditions. Aromatic hydrocarbon derivatives, in this type of reaction, generally use palladium inorganic salt plus ligand as the catalytic system, the catalytic effect of palladium is better among many transition metal elements, the catalytic activity is high, and the substrate is wide, but this method The amount of catalyst is relatively large, and the operation is troublesome. The ligand is usually a relatively expensive phosphine ligand that is sensitive to oxygen and water in the air. The catalytic system needs to be carried out under inert gas protection and anhydrous conditions. In addition, Phosphine ligands are mostly toxic and cannot be widely used in industrial production, especially in the synthesis of drug molecules or drug intermediates

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