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Slow release preparation of cefaclor

A slow-release preparation, cefaclor technology, applied in the direction of inorganic non-active ingredients, polymer compound non-active ingredients, oil/fat/wax non-effective ingredients, etc., can solve the problem of affecting drug efficacy, inconvenience, and affecting drug steady-state blood Drug concentration and other issues to achieve the effect of improving effectiveness or adaptability and reducing the number of medications

Inactive Publication Date: 2007-07-25
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking medicine multiple times a day brings inconvenience to patients, and at the same time, due to the influence of sleep time and other factors, it affects the steady-state blood drug concentration of the drug, thereby affecting the efficacy of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of Embodiment 1-Cefaclor Sustained-release Tablets (1)

[0050] Method: Take 250 grams of cefaclor, 50 grams of hydroxypropyl cellulose, 15 grams of hypromellose, 10 grams of lactose, 10 grams of microcrystalline cellulose, 1 gram of carbomer, and 30 grams of polyethylene glycol 4000 , mixed evenly, dry granulated, mixed with magnesium stearate, and tableted to obtain a finished product, with a drug content of 250mg / tablet. The dissolution rate of the cefaclor sustained-release tablet (1) in 900 ml of water at 37° C. was then determined. After release measurement, the results are shown in Table 1, which meets the requirements.

[0051] The dissolution rate of table 1 cefaclor sustained-release tablet (1)

[0052] Sampling time (hours)

Embodiment 2

[0053] Preparation of Embodiment 2-Cefaclor Sustained-release Tablets (2)

[0054] Method: Take 250 grams of cefaclor, 10 grams of hydroxypropyl cellulose, 20 grams of stearyl alcohol, 15 grams of hypromellose, 1 gram of carbomer, and 10 grams of lactose, pass through 80-mesh sieve, grind and mix Evenly, add a 95% ethanol solution of 10% polyvinylpyrrolidone as a binder and stir to make a soft material, granulate through a 16-mesh sieve, dry the granules at room temperature for 2 hours, granulate with a 16-mesh sieve, and then add stearin Magnesium acid 4.5 grams, micropowder silica gel 2 grams, mix evenly, tabletting obtains finished product, and containing medicine amount is 250mg / sheet. The dissolution rate of the cefaclor sustained-release tablet (2) in 900 ml of water at 37° C. was then determined. After release measurement, the results are shown in Table 2, which meets the requirements.

[0055] The dissolution rate of table 2 cefaclor sustained-relea...

Embodiment 3

[0057] The preparation of embodiment 3-Cefaclor sustained release tablet (3)

[0058] Method: Take 250g of cefaclor, 35g of hypromellose, 5g of microcrystalline cellulose, and 1g of carbomer respectively, pass through 80 mesh sieves, mix well, add 95% ethanol solution of polyvinylpyrrolidone with a concentration of 10% Used as a binder and stirred to make a soft material, granulated through a 16-mesh sieve, dried at 60°C for 1 hour, granulated with a 16-mesh sieve, then added with 2.5 grams of magnesium stearate, mixed evenly, and pressed into tablets to obtain a finished product, containing drugs The dosage is 250mg / tablet. The dissolution rate of the cefaclor sustained-release tablet (3) in 900 ml of water at 37° C. was then measured. After release measurement, the results are shown in Table 3, meeting the requirements.

[0059] The dissolution rate of table 3 cefaclor sustained-release tablet (3)

[0060] Sampling time (hours)

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PUM

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Abstract

A slowly-released medicine of cefaclor in the form of dispersing solid is prepared from cefaclor and slowly-releasing skeleton.

Description

[0001] [Technical field] The present invention relates to the sustained-release preparation of cefaclor and its preparation method. [Background technique] [0002] The research and development of sustained-release preparations has a history of more than 40 years. It releases slowly and at a non-constant rate as required in a prescribed environment. Prolonged formulation. This kind of preparation can make the human body maintain this kind of blood drug concentration for a long time, instead of dropping rapidly like ordinary preparations, so as to avoid the "peak and valley" phenomenon that occurs when common preparations are frequently administered, and ensure the safety of the drug. Sexuality, effectiveness or adaptability have been improved, thereby reducing the number of medications, which greatly facilitates patients, especially patients who have been taking medication for a long time. Commonly used oral dosage forms include matrix tablets, microporous coated surface film ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K9/48A61K47/02A61K47/12A61K47/34A61K47/38A61K47/42A61K47/44A61K31/545A61P31/04A61K47/10
Inventor 刘凤鸣
Owner 刘凤鸣
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