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Pharmaceutical composition for treating senile dementia

A composition and drug technology, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of unsure curative effect, low salvianolic acid, low content, etc.

Active Publication Date: 2009-07-15
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing Western medicines for the treatment of senile dementia are mainly drugs for improving cholinergic neurotransmission, such as tacrine, Donepezil, galantamine, huperzine A, etc. Treatment modality produces inconsistent efficacy, making its use controversial
In addition, pro-metabolism drugs, hormone therapy, anti-inflammatory therapy, antioxidants, anti-amyloid, calcium channel blockers, anti-cerebral ischemia, etc. are all exploratoryly used in the treatment of AD and VD, and the curative effect remains to be confirmed.
[0005] Chinese patent CN1546112A discloses that Compound Danshen Tablets can be used to treat senile dementia, and the current clinical use is mainly to treat angina pectoris of coronary heart disease, and its process and quality standards are all formulated for the treatment of cardiovascular system diseases. The technological conditions determine that the contents of tanshinone IIA, salvianolic acid B, danshensu and protocatechualdehyde in the active ingredients of the drug are relatively low, resulting in unsatisfactory curative effect on the treatment of senile dementia; CN1348815A patent also mentions a Compound Danshen dripping pills can be used to treat senile dementia, but there are no fat-soluble components such as tanshinone IIA, protocatechualdehyde and salvianolic acid B in the active ingredients extracted by the preparation process of compound Danshen dripping pills mentioned in the patent. The content is very small, mainly containing danshensu, so it is not effective for the treatment of Alzheimer's disease, but only for the treatment of coronary heart disease and angina pectoris.
However, its content is low when it is used as medicine to treat senile dementia; compound Danshen dripping pills have no tanshinone IIA component, and the content of salvianolic acid B is low

Method used

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  • Pharmaceutical composition for treating senile dementia
  • Pharmaceutical composition for treating senile dementia
  • Pharmaceutical composition for treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] Take 100Kg of Danshen medicinal material (origin: Shandong, batch number 0411053), 30Kg of notoginseng medicinal material (origin: Yunnan, batch number 0412041), crush Danshen medicinal material into small pieces, soak in 8 times the amount of ethanol for 1 hour, heat and reflux for 0.5 hour, filter, and collect Ethanol filtrate, recover ethanol and concentrate to extract I with a relative density of 1.35; dregs are refluxed with 80% ethanol for 1 hour, filter, collect 80% ethanol filtrate, recover ethanol and concentrate to extract II with a relative density of 1.36 ;Finally, reflux with water heat for 1.5 hours, and concentrate the filtrate to the extract III with a relative density of 1.29; grind the notoginseng into a fine powder of more than 80 mesh, mix with the salvia extract I, II and III, and dry at about 90°C 36h, 55Kg of the prepared medicinal active part dry product (dry paste), moisture ≤ 5%. Measured by the above-mentioned high-performance liquid chromatog...

Embodiment 2

[0141]Example 2: Take 150Kg of Danshen medicinal material (origin: Shandong, batch number 0501001), 45Kg of Radix Notoginseng medicinal material (origin: Yunnan, batch number 0412041), break the Danshen medicinal material into small sections, soak in ethanol for 2 hours, heat reflux for 0.5 hour, filter, Collect the ethanol filtrate, recover ethanol and concentrate to obtain extract I; the dregs are refluxed with 80% ethanol for 0.5 hours, filter, collect 80% ethanol filtrate, recover ethanol and concentrate to obtain extract II; finally reflux with water for 1.5 hours, The filtrate was concentrated to obtain extract III. Crush Panax notoginseng into fine powder above 80 meshes, mix with Danshen extract I, II and III, and dry at about 80°C for 50 hours. A total of 72Kg of dry cream was obtained, and the moisture content was less than or equal to 5%.

[0142] Measured by the above-mentioned high-performance liquid chromatography method, each 1g dry paste contains 2.98mg of tan...

Embodiment 3

[0143] Example 3: take 100Kg of Danshen medicinal material (origin: Shandong, batch number 0501021), 30Kg of notoginseng medicinal material (origin: Yunnan, batch number 0501001), crush Danshen medicinal material into small pieces, soak in ethanol for 1 hour, heat reflux for 1 hour, filter, and collect Ethanol filtrate, recovered ethanol and concentrated to obtain extract I; dregs were refluxed with 80% ethanol for 0.5 hours, filtered, collected 80% ethanol filtrate, recovered ethanol and concentrated to obtain extract II; finally refluxed with water for 2 hours, the filtrate Concentrate to obtain extract III. Crush Panax notoginseng into a fine powder of more than 80 mesh, mix with Danshen extract I, II and III, and dry at about 75°C for 70 hours to obtain a dry paste of 50.66Kg with a water content of ≤5%.

[0144] Measured by the above-mentioned high-performance liquid chromatography method, each 1g dry paste contains 2.56mg of tanshinone IIA, 50.03mg of salvianolic acid B,...

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Abstract

The pharmaceutical composition for treating senile dementia relates to a medicinal product using plants as raw materials. It is an oral preparation made of medicinal active parts and conventional pharmaceutical excipients according to the conventional traditional Chinese medicine preparation process. The medicinal active parts are mainly prepared from Danshen and Panax notoginseng. Contains tanshinone II A 1.79~9.01mg, salvianolic acid B 35.87~225.23mg, danshensu 4.93~45.05mg, protocatechualdehyde 0.10~4.50mg, notoginseng saponin R13.14~22.50mg; tanshinone IIA: salvianolic acid B: The weight ratio of danshensu: protocatechualdehyde: notoginseng saponin R1 is 4-20:80-500:11-100:0.2-10:7-50. The medicament provided by the invention is effective in preventing and treating senile dementia; the active ingredient composition, content and ratio of the product are clear; the product quality is controllable and operable; and it can be mass-produced.

Description

technical field [0001] The invention relates to a medicinal product using plants as raw materials, in particular to a medicine for preparing and treating senile dementia. Background technique [0002] Alzheimer's disease is a manifestation of brain dysfunction in the early and old age. It is a disease characterized by mental decline and behavioral personality changes, including Alzheimer's disease (abbreviated as AD), vascular dementia (abbreviated as VD) ), mixed dementia and others such as trauma and Parkinson's dementia, among which Alzheimer's disease and vascular dementia are the two main types of senile dementia, and the prevalence rate accounts for more than 90% of all dementias. [0003] The pathological changes of AD are mainly characterized by senile plaques (SP) and neurofibrillary tangles (NFT). The former is mainly related to the aggregation, fibrosis and deposition of β-amyloid protein (A β). The core component of senile plaques is β-amyloid peptide (β-AP), wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K36/258A61K31/704A61K31/343A61K31/192A61K31/11A61K9/16A61K9/20A61K9/48A61P25/28
Inventor 李楚源林青黄琳肖晓丽王德勤陈薇
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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