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Epidermis needle and its preparing method

A technology of epidermal needle and needle body, applied in the field of epidermal needle, can solve problems such as narrow material range, and achieve the effects of low price, good durability and simple process

Active Publication Date: 2008-08-06
SUZHOU NASHENG MICROELECTRONICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these technologies can improve the permeation rate to varying degrees, the scope of applicable substances is relatively narrow

Method used

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  • Epidermis needle and its preparing method
  • Epidermis needle and its preparing method
  • Epidermis needle and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment one: see attached Figures 1a-1g , attached figure 2 Shown, a kind of manufacture method of metal epidermis needle, comprises the steps:

[0038] a) A stainless steel sheet with a thickness of 500 microns is taken as the metal substrate 1, after being washed with lotion, rinsed with deionized water and dried. Then use chemical vapor deposition to deposit a layer of silicon dioxide with a thickness of 1 micron on both surfaces of the metal as a protective layer 2 for the metal, and spin-coat Shipley 1818 photoresist 3 with a thickness of 2 microns on the silicon dioxide on one side. ( Figure 1a );

[0039] b) Pre-bake (soft bake) at 90°C for 5 minutes, and form a 20×20 array of solid circles with a diameter of 80 microns and a pitch of 200 microns in a unit of 4 square millimeters. The substrate with photoresist is exposed for 4 seconds, then developed and dried at 120°C for about 30 minutes ( Figure 1b );

[0040] c) Spin-coat Shipley 1818 photoresist...

Embodiment 2

[0045] Embodiment 2: A kind of manufacturing method of metal skin needle

[0046] 1) On a stainless steel sheet with a thickness of 1 mm, use a laser to cut square columns with a depth of 150 microns and a size of 200x120 microns.

[0047] 2) The above-mentioned metal sheet is ultrasonically cleaned in ethanol-water, and then placed in an electrolyte solution containing 30% concentrated sulfuric acid and 10% phosphoric acid at 50°C with a current density of 200A / dm 2 After electrolysis for a few minutes, a superficial and bright epidermis needle is obtained, see attached image 3 shown.

Embodiment 3

[0048] Example 3: Rat in vitro transdermal release curve using bovine serum albumin and botulinum toxin as model macromolecules

[0049] Bovine serum albumin and botulinum toxin solutions were used as model macromolecules.

[0050] Take a piece of rat skin without hair, place the cuticle upwards on the mouth of the diffusion cell, put the epidermis needles prepared in Example 1 (400 needles on an area of ​​4 square millimeters, and the distance between the needles is 200 microns) on it , lightly press the epidermal needle with your hand to make micropores on the skin, but do not penetrate the skin. The stratum corneum of the skin faces the drug supply chamber (the concentration of each substance in the supply chamber is 0.1mM, 1ml), and the dermis faces the drug receiving chamber. Fill the receiving chamber with phosphate buffer (pH7.4) preheated to 37°C, seal the sampling port with parafilm, and place it in a constant temperature water bath at 37°C. Under continuous stirring...

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Abstract

The present invention discloses one kind of epidermal needle and its making process and application. The epidermal needle consists of sheet support and needle array on the support, and the needles have length of penetrating through the skin horny layer and not penetrating into the dermal layer. The epidermal needle may be made through etching metal material, and is used in improving the transdermal absorption of macromolecular beautifying cosmetic and in speeding the transdermal administration of macromolecular biological medicine. The present invention has simple production process and low cost, and is suitable for large scale production and durable. The present invention is especially suitable for transdermal release of beautifying cosmetic, diagnosis reagent, vaccine, macromolecular biological medicine, etc.

Description

technical field [0001] The invention relates to an epidermal needle for transdermally introducing a medium, especially a biomacromolecular medium into the human body, in particular to a transdermal beauty cosmetic nutrition product and a macromolecular drug releasing epidermal needle, and the epidermal needle is used to improve macromolecular beauty treatment The transdermal absorption of cosmetic nutrition products and the transdermal delivery rate of biomacromolecular drugs, the present invention also relates to the production method of such epidermal needles. Background technique [0002] Most drugs are currently administered orally in the form of tablets and capsules. However, due to drug degradation in the gastrointestinal tract and the first-pass effect in the liver, many orally administered drugs are largely or completely ineffective before reaching the site of action. Another common way of administration is injection, including subcutaneous injection and intravenous...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00A61B17/00
Inventor 徐百高云华林朝
Owner SUZHOU NASHENG MICROELECTRONICS CO LTD
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