The invention relates to a nanometer silver fluorinated self-etching single bottle dentistry adhesive, belonging to the technical field of dentistry material. The component and the percentage of total weight is: 3.7 to 4.5 percent of initiator, 0.02 to 3.13 percent of additive, 0 to 2.0 percent of nanometer silver antimicrobial, 0 to 60 percent of methyl methacrylate monomer, 20 to 85.3 percent of acidity monomer and 0 to 53.3 percent of solvent. The acidity monomer comprises a phosphoric acid monomer or / and a carbonic acid monomer; the solvent is 0 to 4 kinds of materials selected from ethanol, propanol, normal butanol, acetone, methyl ethyl ketone, ethyl acetate and water. The nanometer silver of the invention can resist multiple bacterial and the nanometer biological ceramic powder canreduce regeneration caries; the single bottle self-etching function simplifies the using procedure; the mixture of multiple solvents with different permittivity can remarkably reduce the self hydrolysis of the acidity monomer and increase the chemical stability.