The invention discloses a resectoscope clamping device for transurethral resection of the prostate, and relates to the technical field of medical equipment. The resectoscope clamping device comprises a fixing mechanism, a rotating mechanism and a clamping mechanism, wherein the fixing mechanism comprises a connecting block; the rotating mechanism comprises a motor, a cross-shaped connecting block, a coupling, a deep groove ball bearing, a bearing positioning table, a big retaining ring, an angular contact ball bearing, a sleeve, a small retaining ring and a rotating connecting plate; and the clamping mechanism comprises a motor, guide rail baffle plates, a section material baseplate, a coupling, a coupling stop dog, a deep groove ball bearing, an optical axis, a ball screw, a feed screw nut, a sliding block, a push rod, a clamping block and a movable clamping block. The resectoscope clamping device has the beneficial effects that an operating knife is fixed on the clamping mechanism; a motor of the rotating mechanism drives the clamping mechanism and the operating knife to rotate for changing the resection angle of the operating knife; the motor of the clamping mechanism is used for driving assemblies of the clamping mechanism to complete the telescoping movement of an electric resection loop of the operating knife; the two-degree-of-freedom movement of the operating knife is realized; and the working intensity of doctors is reduced.