The present application provides a transverse stapler for intraluminal surgery, comprising a control member, a clamping push rod assembly, a positioning needle push rod assembly, a positioning needle driving assembly and a clamping driving assembly, and the positioning needle push rod assembly is sleeved on the clamp Holding the outside of the push rod assembly, the positioning needle push rod assembly and the positioning needle drive assembly are rotatably connected, and the positioning needle push rod assembly and the positioning needle drive assembly are axially relatively fixed and rotate relative to each other, clamping the push rod assembly and the clamp The holding and driving assembly is connected in rotation, and the axial direction between the clamping push rod assembly and the clamping driving assembly is relatively fixed and the two rotate relative to each other, and the control member drives the clamping push rod assembly to rotate to make the clamping member rotate relative to the clamping driving assembly, And the control member drives the positioning needle push rod assembly to rotate through the clamping push rod assembly, so that the positioning needle rotates relative to the positioning needle driving assembly. The steering of the end of the stapler is driven by the rotating control member, which is convenient for the operator to control the steering of the end without the hand-held handle part being rotated, and is convenient to use.