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Multi-Functional Micro and Nanoparticles for Use in Root Canal Therapies

a multi-functional, root canal technology, applied in the field of root canal therapies, can solve the problems of not being able to disrupt bacterial biofilms, not having a significant limiting factor of biocompatibility, and having a physiological pH of 7.4, so as to achieve the effect of reducing the amount of bacterial biofilms

Inactive Publication Date: 2015-03-26
THE GOVERNINIG COUNCIL OF THE UNIV OF TORANTO
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text discusses the benefits of immobilizing photosensitizers on polymeric supports. This can prevent the photosensitizers from causing harmful residues and make them more suitable for use in the body. The use of natural biopolymers like chitosan can also improve biocompatibility. Overall, the patent highlights the technical advantages of immobilizing photosensitizers on polymeric supports.

Problems solved by technology

Although photosensitizers have been conjugated with different readily available synthetic polymers and liposomes, these possess a significant limiting factor of biocompatibility when applied in vivo.
A disadvantage of chitosan is its low solubility at a physiological pH of 7.4 due to its rigid crystalline structure and primary amino group residues.
In addition, it is also know that chitosan requires (more than 24 hours) to eliminate free-floating bacteria and is not able to disrupt bacterial biofilms, which is important in the treatment of root canal treatment.

Method used

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Embodiment Construction

[0054]The present invention provides for a modified polymeric photosensitizer composition that includes photoactivatable nanoparticles of a chitosan polymer which have been conjugated with a Rose Bengal as a photosensitizer. Preferably, the nanoparticles have a size selected at up to about 100 nanometers, preferably between about 60 nanometers and 90 nanometers, and more preferably, about 80 microns. The particles are preferably admixed with a suitable liquid carrier to form a slurry and which, as will be described, act as an antibacterial and remineralization agent for pre-treating the dentin of hollowed-out root canal prior, to placement and cementation of gutta-percha filler material within the hollowed-out tooth root canal in an endodontic therapy.

[0055]In an endodontic treatment using the nanoparticles of the present invention, the dental pulp canal is first exposed. The pulp of the infected root is removed using endodontic files in a conventional manner and allowed to drain. F...

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Abstract

Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibactenal / antibiofilm properties, neutralizing bacterial byproducts and / or chemical / photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and / or to improve surface / interfacial integrity between filling material and connective tissue.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of 35 USC §119(e) to U.S. Provisional Application Ser. No. 61 / 614,235 filed 22 Mar. 2012.SCOPE OF THE INVENTION[0002]The invention relates to nanoparticles for use in the in vivo treatment of connective tissues in root canal therapies, and more particularly chitosan polymer nanoparticles which may optionally be linked with one or more photoactivatable compounds for providing antibacterial / antibiofilm, neutralize bacterial byproducts and / or chemical / photodynamic crosslinking to achieve enhance mechanical properties, chemical stability in connective tissues and / or chemical to improve surface / interfacial integrity between filling material and connective tissue.BACKGROUND OF THE INVENTION[0003]Root canal or endodontic therapies involve the physical removal of the tooth root pulp by using successively larger helical dental files and reamers. The files and reamers penetrate and remove the pulp tissue leaving a hollowed-out root...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K6/00A61N5/06A61C5/04A61C5/02
CPCA61K6/0052A61K6/0035A61K6/0008A61C5/045A61K6/0058A61C5/02A61N5/062A61K6/0038A61K41/0057A61K9/5161A61C5/40A61C5/55A61K6/65A61K6/52A61K6/62A61K6/17A61K6/54A61P41/00
Inventor KISHEN, ANILSHRESTHA, ANNIE
Owner THE GOVERNINIG COUNCIL OF THE UNIV OF TORANTO
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