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Tall gastrodia tuber preparation with resuscitation-inducing function, its making and quality controlling method

A Gastrodia elata and preparation technology, applied in the field of traditional Chinese medicine, can solve the problems of low bioavailability of products, backward dosage forms, and narrow range of applicable people, and achieve the effects of improving bioavailability, high bioavailability, and increasing stability

Inactive Publication Date: 2007-06-20
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage form of this product is backward, and the product quality is not satisfactory, such as capsules are stored for a long time and become sticky; the dosage forms of existing products are not rich enough, the range of applicable people is narrow, the product bioavailability is low, and the drug stability is not ideal; in view of In these situations, it is urgent to find an effective therapeutic drug preparation with a satisfactory therapeutic effect and stable and controllable quality.

Method used

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  • Tall gastrodia tuber preparation with resuscitation-inducing function, its making and quality controlling method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0205] Example 2 of the present invention: Gastrodia elata 750g, Dilong 500g, Shichangpu 750g, Polygala 500g, Rehmannia glutinosa 250g, Cistanche 250g

[0206] Take Shichangpu, Polygala, Rehmannia glutinosa, and Cistanche, add water and decoct twice, the first time for 1.5 hours, the second time for 1 hour, filter in several times, combine the filtrates, and concentrate to a clear paste with a relative density of 1.10-1.15 at 90°C. Cool, add ethanol to make the alcohol content reach 60%, let it stand for 48 hours, and filter; Dilong is soaked in 60% ethanol for 72 hours, filter, the filtrate is combined with the above filtrate, and the ethanol is recovered, set aside, Gastrodia elata is crushed into fine powder , add to the above liquid medicine, mix thoroughly, dry below 80°C, crush into fine powder, add 100g of starch, use 50% ethanol and 1% soybean oil to make soft material, extrude-spheronize pellets: the prepared soft The material is made of pellets, the wet material is s...

Embodiment 3

[0207] Example 3 of the present invention: Gastrodia elata 750g, Dilong 500g, Shichangpu 750g, Polygala 500g, Rehmannia glutinosa 250g, Cistanche 250g

[0208] Take Shichangpu, Polygala, Rehmannia glutinosa, and Cistanche, add water and decoct twice, the first time for 1.5 hours, the second time for 1 hour, filter in several times, combine the filtrates, and concentrate to a clear paste with a relative density of 1.10-1.15 at 90°C. Cool, add ethanol to make the alcohol content reach 60%, let it stand for 48 hours, and filter; Dilong is soaked in 60% ethanol for 72 hours, filter, the filtrate is combined with the above filtrate, and the ethanol is recovered, set aside, Gastrodia elata is crushed into fine powder , add to the above liquid medicine, mix thoroughly, dry below 80°C, crush into fine powder, add 500g of starch, use 90% ethanol and 5% soybean oil to make soft material, extrude-spheronize pellets: the prepared soft The material is made of pellets, the wet material is s...

Embodiment 4

[0209] Example 4 of the present invention: Gastrodia elata 750g, Dilong 500g, Shichangpu 750g, Polygala 500g, Rehmannia glutinosa 250g, Cistanche 250g

[0210] Take Shichangpu, Polygala, Rehmannia glutinosa, and Cistanche, add water and decoct twice, the first time for 1.5 hours, the second time for 1 hour, filter in several times, combine the filtrates, and concentrate to a clear paste with a relative density of 1.10-1.15 at 90°C. Cool, add ethanol to make the alcohol content reach 60%, let it stand for 48 hours, and filter; Dilong is soaked in 60% ethanol for 72 hours, filter, the filtrate is combined with the above filtrate, and the ethanol is recovered, set aside, Gastrodia elata is crushed into fine powder , add to the above liquid medicine, mix thoroughly, dry below 80°C, grind into fine powder, add 4% CMS-Na, use starch slurry with a concentration of 8% as binder, make soft material, and pass through a 20-mesh sieve granules, dried at 60°C, granulated at 20 mesh, added ...

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Abstract

A Chinese medicine in the form of micropill, tablet, dispersing tablet, dripping pill, or particle for treating headache, dizziness, hypomnesia, insomnia, tinnitus, etc is prepared from 6 Chinese-medicinal materials including gastrodia tuber, earthworm, grass-leaved sweetflag rhizome, rehmannia root, etc. Its preparing process and quality control method are also disclosed.

Description

technical field [0001] The invention relates to a Gastrodia elata refreshing preparation for diseases caused by liver-wind insufficiency, a preparation method and a quality control method thereof, belonging to the technical field of traditional Chinese medicine. technical background [0002] Insufficient liver and kidney, headache, dizziness, memory loss, insomnia, unresponsiveness, tinnitus, backache and other symptoms caused by liver wind disturbance are common diseases that threaten the physical and mental health of the people in the world today, bringing great pain to the majority of patients . In order to achieve the purpose of prevention and treatment, many inventors and pharmaceutical companies have done a lot of research, and also provided some therapeutic products; such as: Gastrodia Xingnao Capsules are developed for the treatment of such diseases. However, the dosage form of this product is backward, and the product quality is not satisfactory, such as capsules a...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/00A61P25/04A61P25/20A61P25/00G01N33/90A61K35/64A61K35/62
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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