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Lyophilized powder injection of baikal skullcap root extract and preparation method thereof

A technology of Scutellaria baicalensis extract and freeze-dried powder injection, which is applied in the field of scutellaria baicalensis extract freeze-dried powder injection and its preparation, can solve the problem that the scutellaria baicalensis extract cannot be made into injections, and achieve the effects of definite curative effect, stable quality and high purity

Active Publication Date: 2007-05-16
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the deficiencies in the existing traditional Chinese medicine preparation technology and provide a new dosage form of Scutellaria baicalensis extract, that is to say, the present invention solves the problem that the Scutellaria baicalensis extract cannot be made into injections

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Heat the water for injection to deoxygenate, take 220g of meglumine and dissolve it in 2000ml of deperoxygenated water for injection to make a meglumine solution, take 100g of nicotinamide and 50g of ascorbic acid and dissolve it in 4000ml of deperoxygenated water for injection and add baicalein 80g to make a suspension, then slowly add 2000ml meglumine solution to the above 4000ml suspension under stirring, continue to stir to dissolve all the baicalein, add 6g of filler mannitol, and then add 0.3% of the total weight of the liquid Use activated carbon for the needle, stir at room temperature for 25 minutes, filter with a No. 4 sand plug, and filter with a 0.22μφ300mm sterile membrane under pressure. Pack about 3ml, freeze-dry, and make 1700 bottles of finished products (there is loss in the process of filtering and packing), and the specification of each bottle is to contain baicalein 33mg (activated carbon has adsorption to baicalein).

Embodiment 2

[0043]Ultrasonic deoxygenation of water for injection, dissolving 300g of arginine in 1000ml of deperoxygenated water for injection to make an arginine solution, taking 80g of nicotinamide and 40g of sodium ascorbate and dissolving them in 2000ml of deperoxygenated water for injection and adding baicalein 40g and 40g of baicalin to make a suspension, then slowly add 1000ml of arginine solution into the above 2000ml suspension under stirring, continue to stir to dissolve all baicalein and baicalin, and then add 0.3% of the total weight of the liquid Use activated carbon for the needle, stir at room temperature for 25 minutes, filter with No. 4 sand plug, and filter with 0.22μφ300mm sterile membrane under pressure. Pack about 3ml, freeze-dry, and make 840 bottles of finished products (losses in the process of filtration and packing), each bottle contains 33 mg of baicalein and 33 mg of baicalin (baicalein is adsorbed by activated carbon).

Embodiment 3

[0045] Water for injection is heated to remove oxygen, and 110 g of meglumine is dissolved in 1000 ml of deoxygenated water for injection to make a meglumine solution, and 80 g of acetamide and 40 g of sodium bisulfite are dissolved in 2000 ml of deoxygenated water for injection. Add 80g of baicalin to make a suspension, then slowly add 1000ml of meglumine solution to the above 2000ml suspension under stirring, continue to stir to dissolve all baicalin, and then add 0.3% of the total liquid weight of activated carbon for needles , stirred at room temperature for 25 minutes, filtered with a No. 4 sand core rod, and then filtered with a 0.22μφ300mm sterile membrane under pressure. After the predicted content and pyrogen passed the test, aseptically dispensed into 10ml vials, each bottle was filled with about 3ml , freeze-dried, and made 850 bottles of finished product (there is loss in the process of filtering and subpackaging), and the specification of each bottle is to contain ...

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PUM

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Abstract

The invention relates to a baikal skullcap root extractive freeze dried, which uses Baikal skullcap root extractive as material, assisted with alkali assisting solvent, acidamide assisting solvent, and anti-oxidant, to make the scutellarein stable in alkali solution. The invention is simple.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to the freeze-dried powder injection of scutellaria baicalensis extract extracted from scutellaria baicalensis and a preparation method thereof. Background technique [0002] Scutellaria baicalensis Georgi, a traditional Chinese medicine, is the root of Scutellaria baicalensis, which has the functions of clearing away heat and dampness, purging fire and detoxification, stopping bleeding and preventing miscarriage. [0003] Baicalein and Baicalin are extracts extracted from the dried roots of Scutellaria baicalensis. They have exact chemical structures, and their structural formulas are: [0004] R=H baicalein R=glucuronic acid baicalin [0005] Studies in recent years have found that these two extracts of Scutellaria baicalensis have antibacterial and antiviral effects, especially baicalein has more liver protection, gallbladder diuresis, free radical scavenging and ant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/539A61K9/19A61P31/04A61P31/12A61P1/16A61P39/06A61P35/00
Inventor 胡凯叶杉
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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