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Compressed pharmaceutical compositions comprising peg and electrolytes

A technology of polyethylene glycol and composition, which is applied in the fields of intestinal gas spasm, stagnation of feces, fecal infarction, treatment of constipation and flatulence, and can solve problems such as bad taste of the solution and resistance of patients

Inactive Publication Date: 2007-04-18
NORGINE EURO BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] As with other laxative and bowel cleansing compositions, many patients experience a bad-tasting solution when taking Movicol® or polyethylene glycol-based compositions for stagnant stools
These adverse feelings can lead to the patient's resistance

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0062] A. Example formulations

[0063] Recipe 1

[0064] The following ingredients are mixed in powder form:

[0065] Macrogol 3350 13.125g

[0066] Sodium chloride 0.3507g

[0067] Sodium bicarbonate 0.1785g

[0068] Potassium chloride 0.0466g

[0069] Acesulfame Potassium 0.010g

[0070] Formula 1a further included orange flavor powder (IFF No. 17.02.1247, accounting for 11 wt% of the powder mixture, ie 1.508g) and a salt masking agent (accounting for 3.45 wt% of the powder mixture, ie 0.473g). Formula 1b further included cola-flavored flavoring powder (IFF No. 15.02.3366, accounting for 4.4wt% of the powder mixture, ie 0.603g) and a salt-masking agent (accounting for 3.45wt% of the powder mixture, ie 0.473g). Recipe 1c further included raspberry citric acid flavoring powder (IFF No. 10.84.8966, accounting for 1.5 wt% of the powder mixture, ie 0.206g, raspberry citric acid flavoring powder containing salt-masking agent).

[0071] The salt-masking agent is commercial ...

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PUM

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Abstract

The invention provides a compressed pharmaceutical composition comprising polyethylene glycol of molecular weight from 2000 to 4500, wherein the polyethylene glycol makes up from 80 to 99.5% by weight of the composition, one or more electrolytes for the treatment of constipation, faecal impaction, faecal retention, intestinal gas and cramping, or flatulence; or for orthostatic lavage, colon evacuation or colon cleansing. It has been found, surprisingly, that a compressed pharmaceutical composition comprising PEG for example a solid tablet, is significantly more palatable than previously proposed compositions and is effective when administered. The compressed pharmaceutical composition of the invention comprising polyethylene glycol has been found to have a more agreeable taste and a more agreeable mouthfeel than previously proposed liquid or dry powder or granular compositions.

Description

technical field [0001] The present invention relates to compositions for the treatment of constipation, fecal obstruction, fecal stagnation, gasspasm, flatulence and also compositions for standing enemas, colon purgatives or colon cleansing. The invention particularly relates to compositions useful in the treatment of constipation. The invention still further relates to methods of use of the composition. Background technique [0002] Constipation is a common condition that often causes discomfort. Stool retention in the colon and / or rectum can cause discomfort and headaches. In extreme cases, the presence of hard or dry stools in the rectum can cause prolonged constipation and painful stools. [0003] Many treatments for constipation have been developed, including dietary controls (eg, increasing the fiber content of foods and avoiding foods thought to cause constipation), laxatives, and enemas. Laxatives are agents that promote and assist laxative...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61P1/10A61K9/20A61K33/14A61K9/46A61K33/00A61K45/06
CPCA61K33/00A61K33/14A61K9/0007A61K9/2022A61K31/765A61K45/06A61K31/77A61P1/00A61P1/10A61P1/14
Inventor 诺曼·巴雷斯伊恩·考克斯
Owner NORGINE EURO BV
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