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Lyrate nightshade gelatin and its preparation method and use

A technology of gel and bletilla, which is applied in antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems that the preparation method of bletilla extract gel preparation has not been reported, and achieve texture Fine and even, rapid action, skin comfortable effect

Inactive Publication Date: 2007-04-11
张干元 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It is the first time in China to research and develop Baiying extract as a single medicine. The Chinese patent "Preparation method of Baiying extract from Solanaceae plant", application number 200410051623.8, discloses the preparation method of Baiying extract for the first time At present, there is no report on the preparation method of Baiying extract gel preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 4

[0049] Embodiment 4: the bacteriostasis test of Baiying gel

[0050] During the test, a blank matrix was used to prepare the extract solution of Baiying to prepare a series of concentration of Baiying gel liquid, and then diluted with the corresponding medium, and the final concentrations of Baiying extract were 50, 25, 12.5, 6.25, 3.12 and 1.56 respectively. mg / ml, conduct the test and observe the test results. The results are shown in the table below.

[0051]

[0052] The results show that the minimum inhibitory concentration (MIC) of Baiying gel to Staphylococcus aureus, Escherichia coli, Salmonella, and Candida albicans in the above test bacteria is 100mg / ml; Monas had obvious antibacterial effect, and the blank matrix had strong inhibitory effect on Pseudomonas aeruginosa.

Embodiment 5

[0053] Embodiment 5: Guinea pig skin long-term toxicity test

[0054] Get healthy rats with a body weight of 190-230g, half male and half male, accurately weigh the gel sample obtained in Example 1, and give guinea pigs complete skin and damaged skin respectively with high (1.0ml / only) and low (0.5ml / only) two doses. Skin, once a day for 90 consecutive days (one day off every week). During the administration period and recovery period (withdrawal for 2 weeks), the general condition of the animals was good, and the main hematological indicators, biochemical indicators, urinalysis indicators, etc. all belonged to the normal range, and there was no statistical difference compared with the blank control group; There were no obvious pathological changes in major organs. Therefore, this product is safe to use under clinical dosage.

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Abstract

This invention relates to the field of medical preparations, revealing a Lyrate nightshade gelatin and its preparation method and use. Performance and quality of the gelatin processed by the method of this invention is table. Compared with the common used external applied soft creams, the lyrate nightshade gelatin has many strong points: easy outspreading of its coated cloth, easy absorbed, fast action, without greasiness. Animal test results indicate that the gelatin can be used effectively to treat eczema and fungal skin disease. Toxin tests show that the gelatin is clinically safe. It can be safely and effectively externally used to treat chromic moist symptom, dermatistis, mycodermatitis. In the lyrate nightshade gelatin of this invention, the abstract from lyrate is 0.5-20%, gelatin matrix 1.5-30%, transdermal accelerant 0.05-8.0%, the moisture remaining agent 1.0-20%, the antiseptic 0.15-8.0% of the weight of the gelatin.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines and natural medicine preparations, in particular to a jelly extract gel and a preparation method and application thereof. technical background [0002] Baiying (Solanum lyratum Thunb) and Millennium Buluxin (S.cathayanum C.Y.Wu etS.C.Huang) are plants of the same family and genus. They grow in the same environment and often coexist. The two plants are often used together. The whole herb of Baiying contains alkaloids; the heart stem of the Millennium Immortality contains steroidal alkaloids, such as tomatidenoi, solasodine, and soladulcidine. The steroidal alkaloids and saponins contained in Baiying and Millennium Bulanxin all have antibacterial activity, among which tomatine has a stronger effect, and has anti-inflammatory, anti-allergic, anti-itching and immunosuppressive effects; the extract is made by adding different excipients The gel can be used for the treatment of eczema and f...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61K9/00A61P17/00A61P31/10
Inventor 邓韵张干元郭可锦欧杰迪韩振林
Owner 张干元
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