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Oral preparation containing rokuromycin and its making method

A technology of roxithromycin and preparations, applied in the field of therapeutic drugs and its preparation, can solve the problems of slow absorption, low blood drug concentration, long time to reach effective blood drug concentration, etc., achieve fast onset of action, save absorption and distribution The effect of the time limit

Inactive Publication Date: 2007-04-04
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the slow oral absorption of tablets, etc., the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood drug concentration of the drug in the lesion is lower, and the time to reach the effective blood drug concentration in the lesion is also longer. Affect its effective antibacterial potency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1-roxithromycin candy

[0055] Prescription: roxithromycin 125g, sucrose 853g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g, preparation dose 1000 tablets.

[0056] Method: Prepare a mixture of roxithromycin 125g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, and carbomer 934P 2g, grind it, and pass it through a 20-mesh sieve. Take 853 grams of sucrose, heat to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, put it on a product forming machine and extrude, each lozenge weighs 1 gram. Then measure the disintegration time limit of roxithromycin candy in 900ml phosphate buffer (PH=6.8) at 37 ℃ and the dissolution rate when disintegrating completely.

[0057] Results: The disintegration time limit is 8-15 minutes, and the dissolution rate when completely disintegrated is 82%-86%.

Embodiment 2

[0058] Embodiment 2-low sugar roxithromycin candy (1)

[0059] Prescription: Roxithromycin 125g, sucrose 203g, fructooligosaccharide 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g, dosage 1000 tablets .

[0060] Method: Prepare a mixture of roxithromycin 125g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, and carbomer 934P 2g, grind it, and pass it through a 20-mesh sieve. Take 203g of sucrose, 300g of fructooligosaccharide, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, cool to 85°C, add 125g of roxithromycin after sieving, stir rapidly for 10 minutes, and place in the product Extruded on a molding machine, each lozenge weighs 1 gram. Then measure the disintegration time limit of roxithromycin candy in 900ml phosphate buffer (PH=6.8) at 37 ℃ and the dissolution rate when disintegrating completely.

[0061] Results: The disintegration time limit is 8-15 minutes, and the dissolution rate wh...

Embodiment 3

[0062] Embodiment 3-low sugar roxithromycin buccal tablet (1)

[0063] Prescription: roxithromycin 125g, gelatin 240g, glycerin 60g, water 60g, fructooligosaccharides 133g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, magnesium stearate 10g, Carbomer 934P 2g, the dosage is 1000 tablets.

[0064] Method: prepare 240g of gelatin, 60g of glycerin, and 60g of water, dry it, then add 125g of roxithromycin, 133g of fructooligosaccharide, 300g of xylitol, 50g of inulin, 10g of citric acid, 400.1g of food coloring, mannitol 10g, Carbomer 934P 2g mixture, grind, pass through a 20-mesh sieve, granulate with ethanol and water, dry at 60°C, then add 10 grams of magnesium stearate, mix well, place on a tablet machine and extrude, each tablet The lozenge weighs 1 gram. Then determine the disintegration time limit and the dissolution rate of the roxithromycin buccal tablet in 37 ℃ 900ml phosphate buffer (PH=6.8) and complete disintegration.

[0065] Resu...

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PUM

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Abstract

An orally absorbed medicine in the form of buccal lozenge, sweets, or dripping pill dissolved by saliva features that it contains roxithromycin. Its preparing process is also disclosed.

Description

[0001] [Technical Field] The present invention relates to a therapeutic drug and its preparation method, especially the buccal preparation containing roxithromycin and its preparation method. [Background technique] [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by group A streptococcus a...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/20A61K9/48A61K31/7048A61P31/04
Inventor 刘凤鸣
Owner 刘凤鸣
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