Thymopentapeptide active isomer and application thereof in pharmaceutical preparation

Abstract

The present invention is active thymic peptide 5 (TP-5) isomer and its pharmaceutical application, and belongs to the fields of organic chemistry and chemical medicine. Structurally, the active TP-5 isomer has TP-5 amino sequence of Arg-Lys-Asp-Val-Tyr with one or two amino acids substituted by corresponding beta-amino acids or gamma-amino acids. It is prepares through a conventional Fmoc solid peptide synthesizing process. Phamacodynamical experiment shows that the active TP-5 isomer possesses obvious immunological enhancement effect, antitumor effect and antioxidant effect. Extracorporeal activity and stability measurement shows that the active TP-5 isomer has activity not lower than that of TP-5, raised stability, longer half life and thus enhanced curative effect. The present invention provides theoretic base for the research on the activity mechanism of thymic peptide and the development of new medicine.

Description

Thymopentin active isomer and its application in medicine preparation technical field The invention belongs to the field of organic chemistry and chemical medicine, and particularly relates to the active isomer of thymopentin and its application in the preparation of immune regulation medicine, antitumor medicine and antioxidant medicine. Background technique The thymus is the primary lymphoid epithelial tissue, the primary central immune organ of the human body, and the central organ of T cell development. In addition to providing a microcirculation required for T cell development, it can also produce a variety of thymosin hormones. Thymus hormones can promote the differentiation and maturation of T cell subsets, thereby regulating the function of the entire immune system. After mammals mature, the thymus gradually shrinks and degenerates with age, and the secretion of thymus hormones also gradually decreases. A large number of research results have shown that senile in...

AI Technical Summary

Problems solved by technology

For healthy individuals, it is normal for peptide hormones to be cleared quickly after they play a regulatory role in the body, but for patients, when medication is needed, the short half-life is not good for treatment.

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