Complex traditional Chinese medicine preparation for treating myocardial ischemia and improving microcirculation and preparing method thereof

Abstract

The invention relates to a Chinese traditional compound medicine and the preparative way of it, which is used to treat myocardial ischemia and improve the microcirculation. The medicine is made up with American ginseng and ophiopogonis and the main ingredients are American ginseng diol group saponin, para-panaxsaponin F11, ophiopogonis Steroid saponin and ophiopogonone, of which American ginseng diol group saponin can't be less than 14.848g, while the American ginseng three groups saponin can't be less than 8.016g. The medicine can be made into different dosage forms such as parenteral solution, high-capacity parenteral solution, freeze-drying powder ampul and so on. The administration route is through intravenous injection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine compound preparation clinically used for treating myocardial ischemia and improving microcirculation and a preparation method thereof. The traditional Chinese medicine compound preparation is made of Chinese medicine compatible with American ginseng and Ophiopogon japonicus, and the preparation contains American ginseng diol group saponins, pseudoginsenoside F 11 , Ophiopogon japonicus steroidal saponins and Ophiopogon japonicus flavonoids, which can be made into dosage forms including injection, large-volume injection, freeze-dried powder injection, etc., and the route of administration is intravenous injection. Background technique [0002] Cardiovascular disease is a common multiple disease, which seriously affects the physical and mental health and daily life of patients. The existing therapeutic drugs include Shenmai injection, which is compo...

AI Technical Summary

Problems solved by technology

[0009] Chinese patent "A pharmaceutical composition containing effective parts of American ginseng and Ophiopogon japonicus and its preparation method" (application number 200410080241.8), the content of ginsenosides in the effective parts of American ginseng extracted by this method (take ginsenoside Rg, Rb↓[1] , Re) is 50%-85%, wherein the ginsengdiol saponin (calculated as ginsenoside Rb↓[1]) in the control ginsenoside is 10%-30%, it can be inferred that in the effective parts of American ginseng extracted by this method Contains a large amount of 20s-protopanaxatriol group saponins (PQTS), and 20s-protopanaxatriol group saponins (PQTS) mainly contains monomeric saponin Rg 1 , Re, but after consulting the literature, it is found that the 20s-protopanaxatriol group saponin (PQTS) contained in American ginseng saponin (PQS) is the main component of its hemolysis, and it is difficult to dissolve in water, which affects PQS to make injections, so it is not suitable for Emergency treatment of ischemic heart disease (Sui Dayuan, Yu Xiaofeng, Qu Shaochun, etc. Protective effect of American ginseng 20s-protopanaxadiol group saponins on acute myocardial infarction in dogs [J]. Chinese Journal of Traditional Chinese Medicine, 2001, 26( 6): 417.)

[0010] It can be seen that the drugs for the treatment of cardiovascular diseases recorded in the prior art still have certain defects. For this problem, medical workers are still constantly looking for more effective clinical prescriptions without adverse reactions.