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Medicine for treating cardiovascular and cerebrovascular disease

A technology for cardiovascular and cerebrovascular diseases and traditional Chinese medicine, applied in the field of traditional Chinese medicine compositions for the treatment of cardiovascular and cerebrovascular diseases, can solve the problems of inability to take care of themselves, relatives and social burdens, etc., and achieve a quality controllable, easy industrialization, and huge social benefit Effect

Inactive Publication Date: 2007-02-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The percentage of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people died of cardiovascular and cerebrovascular diseases every year, and some patients survived despite rescue. , but most of them are disabled and unable to take care of themselves, causing serious burden to relatives and society

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Preparation of Salvia miltiorrhiza extract: Take Danshen decoction pieces or crushed Salvia miltiorrhiza, decoct twice with water, add 6.5 times the weight of the medicinal material each time, 2 hours each time; combine the extracts, adjust the pH to 2 with acid, let cool, filter The resin volume on the filtrate is equivalent to the AB-8 type macroporous resin (produced by Nankai University Resin Factory, Tianjin) column with 3 times of the crude drug, first wash with 1.5 times of column volume water, discard the washing solution, and then use 2.5 times of column volume Elute with 95% ethanol, collect the eluate; concentrate the eluate under reduced pressure until the specific gravity of the extract is 1.15, and dry under reduced pressure to obtain the Danshen extract. The Danshen extract contains 4.5% danshensu, 57.1% total phenolic acid and 27.5% salvianolic acid B.

[0105] The preparation of notoginseng triol saponin extract: take the pulverized notoginseng, add wat...

Embodiment 2

[0109] Preparation of Salvia miltiorrhiza extract: Take Danshen decoction pieces or crushed Salvia miltiorrhiza, add water and ultrasonically extract 2 times, add water 6 times the weight of the medicinal material for 40 minutes each time; combine the extracts, adjust the pH to 2.5 with acid, let cool, filter The resin volume on the filtrate is equivalent to the D101 type macroporous resin (produced by Nankai University Resin Factory, Tianjin) column of 3 times of the crude drug, first wash with 1.0 times of column volume water, and the washing solution is discarded, and then use 95% of 3 times of column volume Eluted with ethanol, collected the eluate; the eluate was concentrated under reduced pressure until the specific gravity of the extract was 1.15, and dried under reduced pressure to obtain the Danshen extract. The salvia miltiorrhiza extract has a danshensu content of 4.6%, a total phenolic acid content of 54.6%, and a salvianolic acid B content of 26.4%.

[0110] Prepa...

Embodiment 3

[0114] Preparation of Salvia miltiorrhiza extract: Take Danshen decoction pieces or crushed Salvia miltiorrhiza, decoct twice with water, add 6.5 times the weight of the medicinal material each time, 2 hours each time; combine the extracts, adjust the pH to 2 with acid, let cool, filter The resin volume on the filtrate is equivalent to the ZTC type macroporous resin (produced by Tianjin Nankai University Resin Factory) column of 3 times of crude drug, first wash with 1.5 times of column volume water, and the washing solution is discarded, and then use 95% of 2.5 times of column volume Eluted with ethanol, collected the eluate; the eluate was concentrated under reduced pressure until the specific gravity of the extract was 1.12, and dried under reduced pressure to obtain the Danshen extract. The salvianolic acid B content of the salvia miltiorrhiza extract is 4.1%, the total phenolic acid content is 53.6%, and the salvianolic acid B content is 24.8%.

[0115] Preparation of not...

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PUM

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Abstract

The invention discloses a medicament for treating cardiovascular and cerebrovascular diseases, which comprises astragalus root saponin extract 35.0-75%, red sage root extract 15.0-55.0%, panaxtriol saponins extract 2.5-15.0%, and natural borneol or rosewood oil 2.5-15.0%. The content of danshensu in the salvia miltiorrhizae extract is 3-10%, the content of total savianolic acid is 50-75%, the content of salvianolic acid B is 20-45%, the content of total saponins in panaxtriol saponins extract is 80-90%, the content of total saponins in astragalus root saponin extract is 70-98%, the content of Astragaloside IV is 5-15%. The composition has evident functions in resisting cerebral ischemia and myocardial ischemia, the curative effect is better than the application of single extract of red sage root or panaxtriol saponins, thus providing a more effective and more convenient Chinese medicinal composition and preparation clinically.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural areas or cities. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth among the causes of death in my country, and rose to second and third respectively after 1975. Cardiovascular and cerebrovascular diseases accounted for the first place among all causes of death. The percentage of deaths due to cardiovascular and cerebrovascular diseases in the total death population in my country has risen from 12.07% in 1957 to 42.6% in 2001, and 2 million people died of cardiovascular and cerebrovascular diseases every year, and some patients survived ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/14A61K9/20A61P9/00A61K31/045
Inventor 叶正良李旭张文生魏峰李德坤
Owner TIANJIN TASLY PHARMA CO LTD
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