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Application of p-hydroxybenzoic acid and its analogue in the preparing process of medicine for preventing and treating skin mucous membrane virus infection

A technology of parahydroxybenzoic acid and viral infection, which can be used in skin diseases, preparations for skin care, botanical equipment and methods, etc., and can solve problems such as long treatment time

Active Publication Date: 2007-02-07
SHENGHUA GUANGZHOU PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment drugs include herpesnet, cytarabine, vidarabine, bromouridine and acyclovir, etc., but the treatment time is longer, and it takes 5 to 7 days

Method used

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  • Application of p-hydroxybenzoic acid and its analogue in the preparing process of medicine for preventing and treating skin mucous membrane virus infection
  • Application of p-hydroxybenzoic acid and its analogue in the preparing process of medicine for preventing and treating skin mucous membrane virus infection
  • Application of p-hydroxybenzoic acid and its analogue in the preparing process of medicine for preventing and treating skin mucous membrane virus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 The preparation of anti-HPV virus microemulsion disinfectant

[0038] Take 20ml of 1,2-propanediol, 15ml of Tween 80, and 5ml of azone, mix them, add sterilized distilled water until the total volume is 100ml, and obtain an external preparation solution. Get p-hydroxybenzoic acid, gallic acid, 10g of 2,4-dihydroxybenzoic acid, add 50ml of external preparation solution respectively, adjust pH to 5.5, then add external preparation solution to 100ml, obtain 10% p-hydroxybenzoic acid, gallic acid, 2,4-Dihydroxybenzoic acid microemulsion.

Embodiment 2

[0039] Example 2 Preparation of Compound Gallic Acid Effervescent Tablets

[0040] Take 0.25g of gallic acid, 0.01g of polymyocytes, and 0.45g of tartaric acid to pass through a 80-mesh sieve respectively, make a soft material with 95% ethanol, pass through a 12-mesh sieve to make wet granules, dry at 50°C, and set aside. Separately take 0.65g of sodium bicarbonate, 0.02g of dextrin and add sterile distilled water to make soft materials, pass through a 12-mesh sieve to make wet granules, dry at 50°C, then mix with the above-mentioned dry granules, granulate, add appropriate amount of sterilized distilled water, and dry After a while, add 0.01g PEG6000. Mix well, press into tablets, and get ready.

Embodiment 3

[0041] Example 3 Fluorescent quantitative PCR detection of HPV virus screening drug experiment

[0042] Drug sample preparation:

[0043] Take 20ml of 1,2-propanediol and 15ml of Tween 80 as solvents, and respectively dissolve benzoic acid, salicylic acid, p-hydroxybenzoic acid, 3,4-dihydroxybenzoic acid, gallic acid, and 2,3-dihydroxybenzoic acid , 2,4-dihydroxybenzoic acid is prepared into a 0.01mol / L solution, and the pH is adjusted to 5.5.

[0044] Source of HPV virus:

[0045] Condyloma acuminatum specimens from clinical standards of many patients were cut and washed with normal saline to remove the blood. Under sterile conditions, the specimens were cut into pieces, mixed with 3 times the volume of normal saline, ground into a homogenate and stored at -40°C for later use .

[0046] experiment method:

[0047] Grouped as shown in Table 1, each group took 50 μl of condyloma acuminata tissue homogenate, and added 50 μl of each test drug solution. Incubate at 37°C for 2...

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PUM

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Abstract

The invention discloses an application of p-hydroxybenzoic acid and analogue in the skin virus infection drug, which is characterized by the following: fitting for infectious drug of people breast tumour virus and herpetoviridae virus; allocating each auxiliary material to prepare different agent or personal nursing product.

Description

technical field [0001] The invention relates to the application of p-hydroxybenzoic acid and its analogs in the preparation of medicines for preventing and treating skin and mucous membrane infection. More specifically, it relates to the application of p-hydroxybenzoic acid and its analogs in the preparation of drugs for preventing and treating human and animal skin and mucous human papillomavirus and herpes virus infections. Background technique [0002] 2-Hydroxybenzoic acid (salicylic acid) has been used in the treatment of bacterial and fungal infectious diseases of the skin and mucous membranes. P-hydroxybenzoic acid and its esters are used as preservatives in food and medicine. Gallic acid (ie 3,4,5-trihydroxybenzoic acid) is often used as an antioxidant, and has been proven to have an inhibitory effect on hepatitis B HBV virus (Journal of Guangzhou Medical College of the People's Liberation Army, 1998, 26 (2) :5-7). But so far there is no related literature to reco...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K8/365A61Q19/10A61K9/00A61K9/12A01N37/10C11D3/48A61P31/12A61P31/22A61P17/00
CPCA61K9/0034A61K9/0043A61K31/192A61P31/12A61P31/22
Inventor 张庆民秦卫华
Owner SHENGHUA GUANGZHOU PHARMA SCI & TECH
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