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Astringing and diarrhea relieving oral dispersion tablet preparation for treating acute and chronic diarrhea gastritis and preparing method

A chronic diarrhea and astringent intestinal antidiarrheal technology, applied in the direction of medical preparations containing active ingredients, pill delivery, pharmaceutical formulas, etc., can solve problems such as inconvenient taking, inaccurate dosage, and earthy smell, and achieve convenient transportation and portability , the dosage is easy to grasp, and the effect of suitable taste

Inactive Publication Date: 2007-01-24
刘庆芸
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, the dosage form of Astringent Chang Zhixie Powder in the market is powder. This dosage form has certain disadvantages. It is inconvenient to take, and the dosage is not easy to master. Add water and stir evenly, and take it orally. It has a gritty feeling and an earthy smell. Patients should not Acceptance, especially when infants and adolescents reduce the dosage, there are certain difficulties, the dosage is not accurate, and the ideal curative effect cannot be obtained

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The distribution ratio of each component: montmorillonite 1000g, Yantuo 1660g, microcrystalline cellulose 100g, carboxymethyl starch sodium 30g, vanillin 1.34g, aspartame 1.0g, microcrystalline silica gel 3g, 85% ethanol 800ml;

[0018] Preparation method: take Yantuo 1660g, make it into extract (Yantuo extract preparation process: Yantuo is crushed into coarse powder, soak three times with 80% ethanol, soak for the first time for 48 hours, 80% ethanol consumption is 10 times the weight of Yan Tuo; soak for 24 hours each for the second and third times, and the amount of 80% ethanol is 5 times the weight of Yan Tuo; then merge the soaking solution, reclaim ethanol under reduced pressure and concentrate to 60 ° C. The relative density is 1.10-1.20 extract, add hydrochloric acid to adjust the pH value to 2; then stand overnight, filter, and concentrate the filtrate under reduced pressure to a thick paste with a relative density of 1.20-1.40 at 50°C, add 5 times the amount o...

Embodiment 2

[0020] The distribution ratio of each component: montmorillonite 1000g, Yantuo 1660g, microcrystalline cellulose 200g, sodium carboxymethyl starch 21g, vanillin 1.34g, magnesium stearate 3.5g, 80% ethanol 850ml;

[0021] Preparation method: Weigh 1660g of Yantuo, make it into extract (the preparation process of Yantuo extract is the same as in Example 1), then mix it with 1.34g of vanillin; then mix it with 200g of microcrystalline cellulose and 1000g of montmorillonite Mix with 7g sodium carboxymethyl starch, then use 850ml 80% ethanol as a wetting agent to make a soft material, dry, and granulate; then add 14g sodium carboxymethyl starch and mix evenly, and then add 3.5g magnesium stearate , mixed evenly, tabletted to prepare 1000 Astringent Chang Zhixie Dispersible Tablets, which are then packaged and put into storage.

Embodiment 3

[0023] The distribution ratio of each ingredient: montmorillonite 1000g, Yantuo 1660g, microcrystalline cellulose 50g, sodium carboxymethyl starch 50g, stevioside 1.3g, talcum powder 2.5g, 90% ethanol 850ml;

[0024] Preparation method: Weigh 1660g of Yantuo, make it into extract (the preparation process of Yantuo extract is the same as in Example 1), then mix it with 1.3g of stevioside; then mix it with 50g of microcrystalline cellulose and 1000g of montmorillonite Mix with 20g of sodium carboxymethyl starch, then use 850ml 90% ethanol as a wetting agent to make soft material, dry, and granulate; then add 30g of sodium carboxymethyl starch and mix evenly, then add 2.5g of talcum powder, mix Uniformly, tabletting, made 1000 pieces of Astringent Chang Zhixie Dispersible Tablets, which are then packaged and put into storage.

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Abstract

The present invention discloses a kind of astringing and diarrhea relieving orally taken dispersive tablet and its preparation process. The tablet is prepared with the main material including montmorillonite and rhizome of featherleaf rodgersflower and supplementary material including filler, disintegrating agent, corrective and flow aid in certain weight proportion. The astringing and diarrhea relieving orally taken dispersive tablet is used in treating acute and chronic diarrhea, gastritis, esophagitis, colitis, GERD, etc of adult and children.

Description

technical field [0001] The invention relates to an oral dispersible tablet preparation for astringent intestine antidiarrheal, in particular to an oral dispersible tablet preparation for astringent intestine antidiarrheal for treating acute and chronic diarrhea gastritis and a preparation method thereof. Background technique [0002] Montmorillonite has been used for many years at home and abroad as an efficient digestive tract protective agent and an adsorbent for viruses, bacteria and their toxins in the treatment of acute and chronic diarrhea. Whether it is for the treatment of acute and chronic diarrhea or various inflammations of the digestive tract mucosa, it has shown its unique protective effect on the mucosa and the repair effect on the epithelial cells of the digestive tract. This effect is not found in other antidiarrheal drugs. Montmorillonite has a strong positioning ability. It does not have the function of inhibiting intestinal peristalsis, therefore, it can...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/20A61P1/12A61K33/06
Inventor 刘庆芸
Owner 刘庆芸
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