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A composite bergenin dispersible tablet and preparation method thereof

A technology of petracenin and dispersible tablets, which is applied in the field of improvement of compound petracenin oral preparations, can solve problems such as difficulty in swallowing, and speed up the dissolution rate

Inactive Publication Date: 2006-11-22
马晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, aiming at the problem of dysphagia of elderly and children patients, the solution of the present invention is to formulate petracenin into a compound petracenin dispersible tablet that can be directly swallowed, chewed, or taken after water dispersion, which is convenient to use, both It can speed up the dissolution rate and help the drug to take effect quickly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1 wt wt%

[0042] Begenin 125.0g 87.6

[0043] Chlorpheniramine Maleate 1.9g 1.3

[0044] Sodium carboxymethyl starch 9.0g 6.3

[0045] Magnesium stearate 1.0g 0.7

[0046] Micronized silica gel 1.6g 1.1

[0047] Aspartame 0.6g 0.4

[0048] Sodium lauryl sulfate 0.6g 0.4

[0049] Polyvinylpyrrolidone 3.0g 2.1

[0050] Made into 1000 pieces

[0051] First micronize petracenin, chlorpheniramine maleate, aspartame, sodium carboxymethyl starch, magnesium stearate, micropowder silica gel, etc., and pass them through a 100-mesh sieve;

[0052] Weigh 3.0 g of polyvinylpyrrolidone to make a 5% aqueous solution, then add 0.6 g of surfactant sodium lauryl sulfate (the concentration is 1%), and set aside.

[0053] Weigh 1.9g of chlorpheniramine maleate, firstly mix it with 9.0g sodium carboxymethyl starch in equal increments, then add 125.0g petracenin and mix thoroughly, then add 0.6g aspartame and sieve , mix well,...

Embodiment 2

[0055] Example 2 wt wt%

[0056] Begenin 125.0g 84.5

[0057] Chlorpheniramine Maleate 3.0g 2.0

[0058] Sodium carboxymethyl starch 14.5g 9.8

[0059] Magnesium stearate 2.2g 1.5

[0060] Micropowder silica gel 0.7g 0.5

[0061] Aspartame 0.7g 0.5

[0062] Sodium lauryl sulfate 0.3g 0.2

[0063] Polyvinylpyrrolidone 1.5g 1.0

[0064] Made into 1000 pieces

[0065] First micronize petracenin, chlorpheniramine maleate, aspartame, sodium carboxymethyl starch, magnesium stearate, micropowder silica gel, etc., and pass them through a 100-mesh sieve;

[0066] Weigh 1.5g of polyvinylpyrrolidone to make a 5% aqueous solution, then add 0.3g of surfactant sodium lauryl sulfate (the concentration is 1%), and set aside.

[0067] Weigh 3.0g of chlorpheniramine maleate, firstly mix with 14.5g of sodium carboxymethyl starch in equal increments, then add 125.0g of petracenin and mix thoroughly, then add 0.7g of aspartame and sieve , ...

Embodiment 3

[0069] Example 3 wt %

[0070] Begenin 125.0g 88.9

[0071] Chlorpheniramine Maleate 1.4g 1.0

[0072] Sodium carboxymethyl starch 7.1g 5.0

[0073] Magnesium stearate 0.7g 0.5

[0074] Micronized silica gel 2.1g 1.5

[0075] Aspartame 0.1g 0.1

[0076] Sodium lauryl sulfate 0.7g 0.5

[0077] Polyvinylpyrrolidone 3.5g 2.5

[0078] Made into 1000 pieces

[0079] First micronize petracenin, chlorpheniramine maleate, aspartame, sodium carboxymethyl starch, magnesium stearate, micropowder silica gel, etc., and pass them through a 100-mesh sieve.

[0080] Weigh 3.5g of polyvinylpyrrolidone to make a 5% aqueous solution, then add 0.7g of surfactant sodium lauryl sulfate (the concentration is 1%), and set aside.

[0081]Weigh 1.4g of chlorpheniramine maleate, first mix it with 7.1g sodium carboxymethyl starch in equal increments, then add 125.0g petracenin and mix thoroughly, then add 0.1g aspartame and sieve , mix well, a...

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Abstract

The compound bergenin disperser tablet consists of bergenin in 82.0-90.0 wt%, chlorphenamine maleate 1.0-2.0 wt%, carboxymethyl starch sodium 5.0-10.0 wt%, magnesium stearate 0.5-2.0 wt%, superfine silica gel powder 0.5-1.5 wt%, sodium dodecyl sulfate 0.1-0.5 wt%, polyvinyl pyrrolidone 1.0-3.0 wt% and aspartame 0.1-0.5 wt%. The compound bergenin disperser tablet is prepared through micronizing the components, mixing, wet pelletizing and tabletting. It may be disintegrated fast within 2 min and has high bergenin and chlorphenamine maleate leaching speed.

Description

Technical field: [0001] The present invention relates to a kind of compound medicine preparation, more specifically, relates to the improvement technology of a kind of compound petrogin oral preparation. technical background: [0002] Bergenin, also known as rock cabbage lactone, phylloxanthin, ghost lamp, and bergamot, is mostly derived from the plant rock cabbage (Bergenia) of the saxifrage family (Bergenia), purple gold bovine plant Dwarf tea, astilbe It is an active ingredient extracted from plants such as astilbe and belongs to isocoumarin compounds. Its main function is to relieve cough and eliminate phlegm, with small adverse reactions, and continuous use does not produce drug resistance. [0003] Chlorpheniramine maleate is H 1 Type receptor blocker, its antihistamine effect is strong, the central nervous system inhibitory effect and anticholinergic effect are weak, so side effects are few, and the dosage is small. It can excite the smooth muscle of bronchi and gas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4402A61K9/20A61K31/366A61P11/10A61P11/14
Inventor 马晶
Owner 马晶
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