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Freeze dried injection powder preparation for treating coronary heart disease and its preparing method

A technology of freeze-dried powder injection and freeze-dried powder injection, which is applied in the field of freeze-dried powder injection for the treatment of coronary heart disease and its preparation, can solve the problems of increased cost input and unfavorable large-scale production, and achieve increased coronary blood flow , Improve blood rheology, improve the effect of myocardial ischemia

Inactive Publication Date: 2006-11-08
耿海波
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method increases the cost input in the production process, which is not conducive to large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 1. Protective effect on myocardial ischemia-reperfusion injury in rats

[0053] Experimental animals and models: male wistar rats, weighing 200-250g.

[0054] Experimental Drug: Guanxinning Injection

[0055] Guanxinning freeze-dried powder injection of the present invention

[0056] Experimental instruments and reagents: MDA kits, SOD kits, GSH·PX kits and P enzyme kits, and other reagents are domestic fractionated pure or biochemical reagents. High-speed desktop centrifuge, XHF-1 high-speed disperser, high-speed refrigerated centrifuge, U-754 spectrophotometer.

[0057] experimental method:

[0058] Ischemia-reperfusion group: Anesthetized by intraperitoneal injection of pentobarbital (50ml / kg), fixed in supine position. After thoracotomy, the left anterior descending coronary artery was ligated for 30 minutes, the ligature was cut and reperfused for 20 minutes to create an ischemia-reperfusion injury model. Myocardial ischemia group: only the left anterior desce...

Embodiment 2

[0072] (1) The proportioning weight of raw materials is

[0073] Salvia miltiorrhiza 2000 grams, Chuanxiong 2000 grams

[0074] (2) Mix red ginseng and Rhizoma Chuanxiong, add 10 amounts of water to soak for 1 hour, extract 3 times, the first time is 2 hours, add 8 times the amount of water for the second and third times, extract for 1.5 hours each, combine the decoction and filter Get the filtrate.

[0075] (3) When the filtrate was concentrated under reduced pressure to 60° C., the relative density was 1.1 to obtain 2000 ml of concentrated solution.

[0076] (4) Add ethanol to the concentrated solution to make the alcohol content reach 75%, place it, filter, reclaim the ethanol, concentrate to a relative density of 1.1, carry out the second ethanol precipitation, add ethanol to make the alcohol content reach 85% and filter, Stand, filter, recover ethanol and concentrate to a relative density of 1.0 to obtain a concentrated solution of 750ml.

[0077] (5) Wet-pack the trea...

Embodiment 3

[0080] (1) The proportioning weight of raw materials is

[0081] Salvia miltiorrhiza 4000 grams, Chuanxiong 4000 grams.

[0082] (2) Mix red ginseng and Rhizoma Chuanxiong, add 10 amounts of water to soak for 1 hour, extract 3 times, the first time is 2 hours, add 8 times the amount of water for the second and third times, extract for 1.5 hours each, combine the decoction and filter Get the filtrate.

[0083] (3) When the filtrate was concentrated under reduced pressure to 60°C, the relative density was 1.1 to obtain 2000 ml of Danshen and Chuanxiong concentrates.

[0084] (4) Add ethanol to the concentrated solution to make the alcohol content reach 75%, place, filter, recover ethanol, concentrate to a relative density of 1.05, carry out second ethanol precipitation, add ethanol to make the alcohol content reach 85% and filter , placed, filtered, recovered ethanol and concentrated to a relative density of 1.0 to obtain 750ml of each concentrated solution.

[0085] (5) Wet-...

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Abstract

The present invention relates to Chinese medicine preparation, and is especially freeze dried injection powder preparation for treating coronary heart disease and its preparation process. The freeze dried injection powder preparation is prepared with red sage and Chuanxiong rhizome as main material, and through the steps of water extraction, precipitating to eliminate impurity, refining with macroporous resin, filtering, compounding the refined extract and freeze drying excipient with injection water to form solution, refining, packing and low temperature freeze drying. Each injection contains protocatechuic aldehyde 10-15mg, total phenolic acid 300-350mg and ligustrazine 10-15mg. The present invention has the advantages of simple preparation process, low cost, high stability, obvious curative effect, etc.

Description

technical field [0001] The invention belongs to traditional Chinese medicine preparations, in particular to a freeze-dried powder injection preparation for treating coronary heart disease and a preparation method thereof. Background technique [0002] Guanxinning Injection is a compound composed of Danshen and Chuanxiong. It has the effects of promoting blood circulation and removing blood stasis, dredging the meridians and nourishing the heart. It is used for angina pectoris of coronary heart disease. Modern pharmacological studies have confirmed that it has the functions of dilating coronary arteries, increasing coronary blood flow, improving myocardial ischemia, inhibiting blood coagulation, promoting fibrinolysis, and improving blood rheology. In recent years, it has been used more clinically. [0003] Guanxinning injection currently used clinically has a low drug concentration, but the clinical dosage is large (50-100ml), and the stability of Guanxinning injection is p...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/19A61P9/10
Inventor 耿海波
Owner 耿海波
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