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Medicine composition for treating productive cough and its use

A composition and pharmacy technology, applied in the field of medicine, can solve the problems of insignificant treatment effect and the like

Inactive Publication Date: 2006-11-08
肖广常 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most expectorant coughs are combined with antitussives and expectorants, but the therapeutic effect is not obvious. Up to now, no combination of ambroxol hydrochloride, guaiacol and levosalbutamol has been used for the treatment at home and abroad. Reports of expectorant cough caused by chronic bronchitis, asthma, recurrent lower respiratory tract infection and other respiratory diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: dosage form: granule

[0029] Ambroxol Hydrochloride 300g

[0030] Guaifenesin 1000g

[0031] Levalbuterol 20g

[0032] Sucrose 5000g

[0033] Dextrin 4000g

[0034] 10% polyvinylpyrrolidone K30 solution appropriate amount

[0035] Made into 10000 bags

[0036] Weigh ambroxol hydrochloride, guaiacol glyceryl ether, levosalbutamol, sucrose and dextrin according to the prescription, pass through a 100-mesh sieve, mix well, add 10% polyvinylpyrrolidone K30 solution to prepare a soft material, pass through a 16-mesh sieve grains, dry. After drying, mix evenly, granulate, and pack into bags.

Embodiment 2

[0037] Embodiment 2: dosage form: powder injection

[0038] Ambroxol Hydrochloride 60g

[0039] Guaifenesin 200g

[0040] Levalbuterol 4g

[0041] Mannitol 200g

[0042] Made 1000 pieces

[0043] Take 60g of ambroxol hydrochloride, 200g of guaiacol glyceryl ether, and 4g of levosalbutamol, add 1.5L of water for injection, stir to dissolve, add 200g of mannitol and stir to dissolve, add water for injection to 2L, add charcoal for needles and stir at room temperature, Filtration decarbonization, fine filtration. The filtrate is divided into 2ml per bottle and freeze-dried to obtain a sterile freeze-dried product.

Embodiment 3

[0044] Embodiment 3: dosage form: water injection

[0045] Ambroxol Hydrochloride 30g

[0046] Guaifenesin 100g

[0047] Levalbuterol 2g

[0048] Tween 80 20g

[0049] Water for injection 10000g

[0050] Made 1000 pieces

[0051] Weigh 20g of Tween 80, place in 8000ml water for injection, stir and dissolve, add 100g guaiacol glyceryl ether, 30g ambroxol hydrochloride and 2g levosalbutamol to the obtained solution, stir and dissolve, add water for injection to 10000ml, stir Mix well, filter, pour, melt seal, and sterilize at 100°C for 30 minutes.

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PUM

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Abstract

The present invention relates to a kind of medicine composition for treating productive cough, and the medicine composition has ambroxol hydrochloride, guaifenesin and levosalbutamol in certain weight proportion and pharmaceutically acceptable supplementary material. The medicine composition may be prepared into pharmaceutically acceptable preparation forms for treating productive cough caused by chronic bronchitis, asthma, repeatable lower respiratory infection and other respiratory system diseases.

Description

(1) Technical field [0001] The invention relates to a medicinal composition for treating expectorant cough and its application, belonging to the technical field of medicine. (2) Background technology [0002] Coughing is a common symptom of respiratory diseases and is a protective respiratory reflex action of the human body. Cough occurs because when foreign bodies, irritating gases, respiratory secretions, etc. stimulate the receptors in the respiratory mucosa, the impulse is transmitted to the medullary cough center through afferent nerve fibers, causing coughing. There are many reasons for coughing. In addition to respiratory organs such as the nose, pharynx, larynx, trachea, bronchi, lungs, and pleura, the vagus nerve of the ear, meninges, heart, esophagus, and stomach is stimulated, and it will also be transmitted to the cough center to cause coughing. [0003] Cough is divided into dry cough and wet cough according to its nature. Cough without sputum or very little s...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K9/12A61K31/085A61P11/10A61P11/14
Inventor 肖广常张颖
Owner 肖广常
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