Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Traditional Chinese cinnamomum cassia extract superfine powder preparation method

A technology of cinnamon extract and ultrafine powder, which is applied in the fields of Chinese herbal medicine preparation and chemical industry

Inactive Publication Date: 2006-10-04
SHANGHAI UNIV
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Supercritical fluid anti-solvent precipitation technology is a technology that realizes the precipitation of solutes from the system to form ultrafine particles through the change of solvent phase. There is no report on the miniaturization of traditional Chinese medicine, especially the miniaturization of Chinese medicine cinnamon extract.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation process and steps of the cinnamon extract in the present embodiment are as follows:

[0016] (1) Using supercritical CO 2 Fluid extraction device to prepare Chinese medicine cinnamon extract: Chinese medicine cinnamon is crushed, sieved and put into supercritical CO 2 Extraction is carried out in a fluid extraction device, and the low-polarity components that have no inhibitory activity on α-glucosidase are removed from the traditional Chinese medicine cinnamon. Ethanol is recovered by internal evaporation to obtain an effective part with strong inhibitory activity on α-glucosidase; this effective part is the Chinese medicine cinnamon extract. (For details of this part, refer to another contemporaneous patent application.)

[0017] (2) with supercritical fluid CO 2 The anti-solvent precipitation device prepares the superfine powder of Chinese medicine cinnamon extract: the above-mentioned Chinese medicine cinnamon extract is formulated into an ethanol...

Embodiment 2

[0019] The preparation process and steps of the cinnamon extract in this embodiment are exactly the same as those in the above-mentioned embodiment 1. The difference is: the extract of traditional Chinese medicine is prepared into ethanol solution with a concentration of 10g / L; the ethanol solution of cinnamon extract is pumped into the expansion chamber through the nozzle at a flow rate of 2ml / min; CO 2 The flow rate is 450g per hour, the pressure of the expansion chamber is controlled at 20MPa, and the temperature is controlled at 40°C; the particle size of the final precipitated ultrafine powder of the extract is 0.6-0.9μm.

[0020] The particle diameter of the extract powder prepared in this example is 0.4-0.9 μm in the micrograph observed by a Hirox three-dimensional video microscope at 5600 times.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The invention relates to a process for preparing superfine powder of Chinese herbal Cinnamomum cassia extract having alpha- glucosidase inhibiting activity, which comprises obtaining effective portion with strong inhibiting activity to alpha-glucosidase from Cinnamomum cassia by means of fluid extraction technique, then formulating ethanol solution of the Cinnamomum cassia extract, carrying out granulation to the extract by employing hypercritical fluid CO2 anti-solvent depositing device. The superfine powder of the extract has good dispersity in water, thus the bioavailability of the medicament can be improved.

Description

technical field [0001] The invention relates to a method for preparing superfine powder of Chinese medicine cinnamon extract with alpha-glucosidase inhibitor activity, and belongs to the technical field of Chinese herbal medicine preparation and chemical engineering. Background technique [0002] The micronization of Chinese herbal medicine particles generally adopts mechanical processing methods such as jet milling and grinding. Chinese herbal medicine can improve and enhance the therapeutic effect of the drug by controlling the size or particle size of the particles; especially for some traditional Chinese medicines with poor water solubility, the dispersion in water can be improved through the miniaturization of Chinese medicine particles, and its drug efficacy and efficacy can be improved. play a therapeutic role. [0003] Supercritical fluid anti-solvent precipitation technology is a technology that realizes the precipitation of solutes from the system to form ultrafin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/54A61K9/14
Inventor 吕敬慈张忠雍克岚陈旭
Owner SHANGHAI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com