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Gel type dexketoprofen plaster and method for preparing the same

A technology of dexketoprofen patch and dexketoprofen, which is applied in the field of medicine, can solve the problems of drug thermal decomposition, difficult to meet the dosage of dexketoprofen, and low drug loading, and achieve increased compliance Sexuality, optimal drug selection, and the effect of enhancing the therapeutic effect

Inactive Publication Date: 2006-09-06
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the patch preparation process described in the patent document CN1565523, the hot-melt pressure-sensitive adhesive needs to be heated above 100°C, which will cause thermal decomposition of drugs such as ketoprofen
[0009] Hydrophobic rubber-type pressure-sensitive adhesives generally have low drug loading. Although the dosage of dexketoprofen is smaller than that of ketoprofen, it is still relatively large (for example, adults take 3-4 times a day, about 25mg each time, that is, Need oral medicine 75-100mg), the pressure-sensitive adhesive matrix in the above-mentioned technical scheme is difficult to meet the larger dosage of dexketoprofen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0055] The preparation of the above-mentioned drug-containing gel type drug storage material is as follows:

[0056] In a reactor with a stirring and heating device, add drug reservoir matrix materials, including high and low molecular weight polyvinylpyrrolidone or copolymers containing vinylpyrrolidone units and polyvinyl alcohol, or polyvinyl alcohol and polyethylene glycol , and add water, stir at a temperature of 60-100°C to mix the components evenly, then control the temperature to 40-45°C, add acid to adjust the pH of the system to 4-5, add a cross-linking agent, and continue stirring for 45-75 minutes , to prepare the gel-type drug depot matrix material.

[0057] In another reactor with a stirring and heating device, add dexketoprofen (content ≥ 98.5%), drug solvent and wetting agent, transdermal absorption accelerator, stir under 60~100 ℃ of temperature, make each component Mix well and allow the medication to dissolve completely. After the medicine is completely di...

example 31

[0077] The composition of the formula is the same as in Example 6, except that the middle drug-containing gel type drug storage material is divided into three layers, from the anti-adhesive material to the backing material, and each layer contains different proportions (the proportion of the total amount of the drug, the same below) Drugs: 25%, 30%, 45%. The preparation method is as follows: mix the matrix material of the drug storehouse, the drug solvent, the moisturizing agent, and the percutaneous absorption accelerator according to the process, divide the mixture into three equal parts, and mix each equal part with the drug in a corresponding proportion. Lay one layer on the backing material, dry it properly before laying the second layer, and spread the third layer in the same way. In this way, the gel-type dexketoprofen patch with the gel-type drug storage material divided into three layers and containing different proportions of drugs is prepared.

example 32

[0079] The composition of the formula is the same as in Example 16, except that the drug-containing gel-type drug storage material in the middle is divided into four layers, from the anti-adhesive material to the backing material, and each layer contains drugs in different proportions: 10%, 20%, 30%, 40%. The preparation method is the same as that in Example 31, except that four layers are laid sequentially from the anti-adhesive material to the backing material according to the corresponding drug ratio.

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Abstract

The invention discloses a gel type dexketoprofen plaster and method for preparation, which comprises backing material, gel type medicament material and anti-sticking material, wherein the medicament material contains 0.5-30.0 wt% of active medicinal constituents, 0.5-40.0 wt% of medicinal solvent, 0.5-30.0 wt% of humectant, and 0.5-8.0 wt% of transderrnal absorption promoting agent, the gel type medicinal material includes high- and low-molecular-weight poly vinyl pyrrolidone or copolymer containing vinyl pyrrolidone unit, polyvinyl alcohol, or polyvinyl alcohol and polyethylene glycol, cross linking agent and water. The invention also discloses its preparation.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a gel-type dexketoprofen patch and a preparation method thereof. Background technique [0002] Ketoprofen (Ketoprofen) is a 2-aryl propionic acid non-steroidal antipyretic analgesic and anti-inflammatory drug. Inflammation, etc., as well as acute sprains or soft tissue contusions. The ketoprofen molecule has a chiral carbon atom, and for a long time, the drug is generally available in the form of racemate for clinical use. The separation of optical isomers found that the L-isomer of ketoprofen is almost inactive, mainly the D-isomer exerts anti-inflammatory, anti-rheumatic and analgesic therapeutic effects, and the anti-inflammatory effect of the D-isomer of ketoprofen is about that of ketoprofen. 2 times (Evans AM. Pharmacodynamics and pharmacokinetics of the profens: enantioselectivity, clinical implications, and special reference to S(+)-ibuprofen. J. Clin. Pharmacol., 1996...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/70A61K47/00A61P29/00
Inventor 刘卫代冬梅陈宏杰周小顺杨祥良
Owner HUAZHONG UNIV OF SCI & TECH
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