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Method for preparing digestive tract stent carried with medicines of micro-/nanometer balls

A nanosphere and digestive tract technology, which is applied in the preparation of microspheres, pharmaceutical formulations, microcapsule preparations, etc., can solve problems such as difficult to achieve therapeutic concentration, strength, elasticity, lack of mechanical properties of polymer materials, etc., and achieve good Particle size and particle size distribution, high encapsulation efficiency and drug loading rate, and the effect of improving bioavailability

Inactive Publication Date: 2006-06-28
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional metal stents and covered stents still have at least the following two shortcomings: ① they do not have real local therapeutic effects, and only play a role of mechanical support—short-term palliative effect of reducing symptoms, and they are powerless to prevent restenosis caused by tumor growth ; Although the covered stent can prevent tumor growth to a certain extent, it still cannot prevent tumor longitudinal overgrowth and compressive restenosis
② After metal stent implantation, it is still necessary to cooperate with systemic drug treatment, but the blood concentration of cancer tissue after systemic drug administration is low, and it is difficult to achieve an effective therapeutic concentration; However, most anticancer drugs have severe side effects, and it is not advisable for most advanced cancer patients who have already developed organ lesions or are extremely weak.
"If this patent is used to prepare digestive tract stents, there are mainly the following shortcomings: First, the mechanical properties of degradable polymer materials are lacking, and the strength and elasticity cannot meet the requirements of digestive tract stents.
The second is that the drug stent obtained by this preparation method has no protective layer, and the limited physical and mechanical properties of degradable polymer materials make it difficult for the stent to be completely delivered to the lesion.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] 1. Preparation of drug-loaded microspheres by heating and curing method:

[0042] Dissolve 250 mg of bovine serum albumin in 1 mL of 1% 5-fluorouracil solution, mix it with 100 ml of cottonseed oil containing 10% Span, stir at 2500 rpm for 10 min, and then ultrasonically emulsify. Take another 100ml of cottonseed oil and heat it to 180°C, gradually add the above emulsion under stirring at 2500rpm, keep warm at 180°C for 10min, continue stirring to room temperature, add 200ml of ether or petroleum ether to degrease, centrifuge at 3000rpm, discard The oil phase was washed with ether and ethanol in turn to obtain 5-fluorouracil microspheres.

[0043] 2. Preparation of microsphere storage layer:

[0044] The microspheres are mixed with the viscous substance PVP to prepare a microsphere reservoir layer and adhered on the backing layer, and the thickness of the reservoir layer is 200um.

[0045] 3. Preparation of backing layer:

[0046] Take 10g of silicone rubber and diss...

Embodiment 2

[0051] 1. Preparation of drug-loaded microspheres by adding cross-linking agent curing method:

[0052] To prepare mitomycin C microspheres, take 10 mg of mitomycin C and 1000 mg of alginate in a ratio of 1:100 (W / W). Firstly, 1 g of alginate was dissolved in distilled water at 80°C to form a uniform viscous liquid with a concentration of 6%, then 10 mg of mitomycin C and 0.5 ml of 0.1% calcium chloride solution were added in sequence, and mixed well. Under the action of acid, high-valent metal ions and other bifunctional cross-linking agents, the mixed solution forms a cross-linked network structure to form a gel, which is then processed and shredded into microspheres with an average particle diameter of 600um.

[0053] 2. Preparation of microsphere storage layer:

[0054] The microspheres are mixed with the viscous substance PVP to prepare a microsphere reservoir layer and adhered on the backing layer, and the thickness of the reservoir layer is 1200um.

[0055] 3. Prepara...

Embodiment 3

[0061] 1. Preparation of drug-loaded microspheres:

[0062] Disperse cisplatin 200 mg into 700 mg of poly-L-propionate in 50 ml of dichloromethane solution, mix it with a mixed aqueous solution containing 0.05% MC and 4% PVA, sonicate it into an O / W type emulsion, distill off di That is obtained after methyl chloride.

[0063] 2. Preparation of micro-nanosphere storage layer:

[0064] The prepared microspheres were mixed with PLGA and added dextrin and bonded with the backing layer. The thickness of the reservoir layer is 200um.

[0065] 3. Preparation of backing layer:

[0066] 2g polyurethane was dissolved in 20ml DMF solution. Dissolve under stirring at 40°C for 6 hours and then pour it onto glass to form a film. The membrane was then glued to the scaffold with silicone glue. The thickness is 20um.

[0067] 4. Preparation of protective film layer:

[0068] Weigh low molecular weight HPMC, add 100ml double distilled water to dissolve, and pour into a self-made unifor...

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Abstract

A process for preparing the scaffold carrying the medicine-carried slow-release nano-balls to treat the benign or malignant stenosis of esophagus and digestive tract includes such steps as preparing micro-balls by one of 4 methods, preparing nano-balls by one of 4 methods, preparing medicine layer, preparing liner layer and preparing protective layer.

Description

technical field [0001] The invention relates to a preparation method in the technical field of medicine and medical equipment, in particular to a preparation method of drug-loaded slow-release micro / nano ball digestive tract stent. Background technique [0002] Gastrointestinal benign and malignant strictures are clinically common diseases. Among them, malignant stenosis of the digestive tract is a high-incidence disease in patients with digestive tract cancer. In addition to surgical resection, radiotherapy and chemotherapy, commonly used interventional methods mainly include balloon dilatation (mainly for benign strictures) and stent placement. For patients with advanced digestive tract cancer, stent implantation is a very important palliative treatment method, which can effectively improve the quality of life and prolong the survival time of patients with advanced digestive tract cancer. However, traditional metal stents and covered stents still have at least the follow...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61F2/04A61K9/22A61L27/00A61L33/00B01J13/02
Inventor 郭圣荣郭庆海
Owner SHANGHAI JIAO TONG UNIV
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