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Reduced glutathione eye medicinal preparation

A technology for pharmaceutical preparations and glutathione, which is applied in the directions of drug combination, pill delivery, tripeptide components, etc., can solve the problems of unstable reduced glutathione solution, low product stability, and impact on product quality, etc. , to achieve the effect of excellent effect, improved stability and simple preparation method

Active Publication Date: 2006-05-24
武汉五景药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention also aims at the instability of the reduced glutathione solution, and the product has a certain irritation. At the same time, because the reduced glutathione itself is easily decomposed in water, the stability of the product is not high, which affects the quality of the product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 2. Process

[0044] (1) Pulverization: Pulverize reduced glutathione, 6-aminocaproic acid, taurine, polyethylene glycol 6000 or polyethylene glycol 4000, sodium lauryl sulfate or magnesium lauryl sulfate respectively Pass through 80-120 mesh sieve;

[0045] (2) Take the prescribed amount of povidone, add dehydrated alcohol or water for injection to dissolve into a solution, and use it as an adhesive;

[0046] (3) Mixing: Take the pulverized reduced glutathione, 6-aminocaproic acid, and taurine in the prescribed amount and mix them evenly with the binder to make a soft material;

[0047] (4) Granulation: Pass the soft material through a No. 10-14 sieve to granulate;

[0048] (5) Drying: 40~75℃, dry for 3~8 hours;

[0049] (6) Grain sizing: pass through No. 12 to No. 16 sieves after drying;

[0050] (7) Total mixing: Add the prescription amount of polyethylene glycol 6000 or polyethylene glycol 4000, sodium lauryl sulfate or magnesium lauryl sulfate into the gr...

Embodiment 2

[0066] Consumption per 10,000 sticks

[0067] Its preparation method is identical with embodiment 1.

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PUM

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Abstract

The present invention relates to a reduced glutathione eye medicine preparation. Said preparation contains two portions: one portion is its active component reduced glutathione and another portion is solvent. Said reduced glutathione is a solid preparation, said solide preparation and solvent are separately packaged. When it is used, the solid preparation can be dissolved in the solvent, so that it can attain the action of stabilizing preparation.

Description

Technical field: [0001] The invention relates to an ophthalmic pharmaceutical preparation, in particular to an ophthalmic pharmaceutical preparation of reduced glutathione. Background technique: [0002] Reduced glutathione, English name: Reduced glutathione for Injection Molecular formula: C10H1806N3S Molecular weight: 308.33. [0003] Reduced glutathione (GSH) is a peptide naturally synthesized in human cytoplasm. It is composed of glutamic acid, cysteine ​​and glycine, contains sulfhydryl (-SH), and is widely distributed in various organs of the body. Cell biological function has been shown to play an important role. It is the prosthetic group of glyceraldehyde phosphate dehydrogenase, and the coenzyme of glyoxalase and triose dehydrogenase, and participates in the tricarboxylic acid cycle and glucose metabolism in the body. This product can activate a variety of enzymes [such as thiol (-SH) enzymes, etc.], thereby promoting sugar, fat and protein metabolism, and can af...

Claims

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Application Information

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IPC IPC(8): A61K38/06A61K9/14A61K9/16A61K9/20A61P27/02
Inventor 范先甲范新兰
Owner 武汉五景药业有限公司
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