Skeleton pattern medicine film encapsulated alimentary tract stent
A skeleton type, digestive tract technology, applied in the field of digestive tract stents, can solve the problems of inability to prevent compressive restenosis due to excessive growth of tumors in the longitudinal direction, lack of local therapeutic effect, difficulty in reaching therapeutic concentration, etc., achieve good drug release effect, good The effects of drug loading capacity and appropriate drug release rate
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Embodiment 1
[0023] The invention comprises: a bracket, a backing layer and a multi-layer skeleton type medicine film layer, the backing layer is wrapped on the surface of the bracket, the backing layer is close to the bracket, and the multi-layer skeleton type medicine film layer is close to the backing layer.
[0024] The material of the backing layer is silicon rubber.
[0025] The multi-layer skeleton type drug film layer is one layer with a thickness of 3000um.
[0026] The drug-loaded polymer material used in the multi-layer skeleton drug film layer is polyurethane.
[0027] According to the requirements of the release rate, the multi-layer skeleton drug film layer contains a substance for regulating the release rate of the drug: porogen low molecular weight polyethylene glycol.
[0028] The anticancer drug contained in the multi-layer skeleton drug film layer is doxorubicin.
[0029] The present invention is used to treat stenosis caused by malignant esophageal tumors, not only ha...
Embodiment 2
[0031] The invention comprises: a bracket, a backing layer, a multi-layer skeleton type medicine film layer and a protective layer, the backing layer is wrapped on the surface of the bracket, the backing layer is close to the bracket, and the multilayer skeleton type medicine film layer is close to the backing layer Above, the protective layer is on the multi-layer framework type drug film layer.
[0032] The material of the backing layer is polytetrafluoroethylene.
[0033] The multi-layer skeleton drug film layer is composed of 10 submicrolayers, and the thickness of the submicrolayer is 20um. The drug loading of each submicrolayer is different, and the drug content of each layer increases sequentially from the outside to the inside.
[0034] The drug-loading macromolecular material used in the multi-layer skeleton drug film layer is ethylene / vinyl acetate copolymer.
[0035] According to the requirements of the release rate, the multi-layer skeleton drug film layer contains...
Embodiment 3
[0040] The invention comprises: a bracket, a backing layer and a multi-layer skeleton type medicine film layer, the backing layer is wrapped on the surface of the bracket, the backing layer is close to the bracket, and the multi-layer skeleton type medicine film layer is close to the backing layer.
[0041] The material of the backing layer is polystyrene.
[0042] The multi-layer skeleton drug film layer is composed of 100 submicrolayers, and the thickness of the submicrolayer is 10um. The drug loading of each submicrolayer is different, and the drug content of each layer increases sequentially from the inside to the outside.
[0043] The drug-loaded macromolecular material used in the multi-layer skeleton drug film layer is polyvinyl alcohol.
[0044] According to the requirements of the release rate, the multi-layer skeleton drug film layer contains a blocker diethyl phthalate.
[0045] The multi-layer skeleton drug film layer contains anticancer drug 5-fluorouracil.
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