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Method for preparing multi-functional biological material for repairing human body

A repair material and multi-functional technology, applied in prosthesis, medical science, surgery, etc., can solve problems such as non-bandage, poor resistance of pigskin, rejection, and disease transmission, and achieve excellent tensile strength and plasticity , good adhesion, wide range of effects

Inactive Publication Date: 2006-03-29
刘炳森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there are no reports of biomaterials for repairing visceral damage. The most ideal cover for burn wounds is cadaver skin. However, the source of cadaver skin is difficult, expensive, and has rejection and transmission of diseases (including hepatitis and AIDS). The risk of pig skin is poor, and it has space occupation and affects epithelial growth. There is no ideal product for artificial skin at home and abroad.
The main disadvantage of the currently disclosed repair materials in China is that they cannot be bandaged and compressed after covering the burn wound, otherwise the membrane is prone to tissue compatibility, that is, the membrane dissolves and the burn wound is exposed, the skin graft is not easy to survive, the burn wound is infected, and even sepsis occurs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 The preparation method of multifunctional biological repair materials for human body, the peritoneum of artiodactyla, ruminant suborder and persydactyla mammals, that is, the selected animals are pigs, dogs, cows, horses, mules, donkeys, sheep or camels fresh The peritoneum is washed with clean water, and the alkaline degreasing and decontamination treatment is carried out physically and chemically, that is, the peritoneum is rubbed and washed with washing powder to remove grease and oil. Soak in 0.3% bromogeramine, or 5% norfloxacin or silver-prepared norfloxacin solution, or use 1% silver sulfadiazine or 0.05% peracetic acid to sterilize chemical drugs. After the chemical medicines are sterilized, soak for 12 hours with a concentration of 0.05% glutaraldehyde solution, soak in a 1% sodium bicarbonate solution for 2 hours after soaking with the glutaraldehyde solution, and then rinse with clear water. After washing with clean water, two kinds of materials, dr...

Embodiment 2

[0024] Example 2 The preparation method of the multifunctional biological repair material for the human body. The peritoneum of mammals of Artiodactyla, Rumininidae, and Persistodactyla is taken, that is, the selected animals are pigs, dogs, cows, horses, mules, donkeys, sheep or camels. The peritoneum is washed with clean water, and the alkaline degreasing and decontamination treatment is carried out physically and chemically, that is, the peritoneum is rubbed and washed with washing powder to remove grease and oil. Soak in 5% bromogeramine, or 0.3% norfloxacin or silver-prepared norfloxacin solution, or use 5% silver sulfadiazine or 0.01% peracetic acid to sterilize chemical drugs. After the chemical medicines are sterilized, soak for 10 minutes with a concentration of 4% glutaraldehyde solution, soak in a 5% sodium bicarbonate solution for 24 hours after soaking with a glutaraldehyde solution, and then rinse with clear water. Wash with clean water to make two kinds of mater...

Embodiment 3

[0025] Example 3 The preparation method of the multifunctional biological repair material for the human body. The peritoneum of mammals of Artiodactyla, Rumininidae, and Persistodactyla is taken, that is, the selected animals are pigs, dogs, cows, horses, mules, donkeys, sheep or camels. The peritoneum is washed with clean water, and the alkaline degreasing and decontamination treatment is carried out physically and chemically, that is, the peritoneum is rubbed and washed with washing powder to remove grease and oil. Soak in 3% bromogeramine, or 10% norfloxacin or silver-prepared norfloxacin solution, or use 10% silver sulfadiazine or 0.03% peracetic acid to sterilize chemical drugs. After the chemical medicines are sterilized, it is soaked in 8% glutaraldehyde solution for 24 hours, then immersed in 8% sodium bicarbonate solution for 13 hours after soaking in glutaraldehyde solution, and then rinsed with clear water. After washing with clean water, two kinds of materials, dry...

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Abstract

A multifunctional biorepairing material for repairing human viscera and pleura and covering the burn skin by it is prepared from the pleura of artiodacty, and ruminantial mammal, flushing with clean water, chemically and physically removing fat and dirt, chemical disinfecting, immersing in glutaraldehyde solution to obtain dry and wet materials, putting it in sealed container, and sterilizing by Co 60 irradiation or epoxy ethane. Its advantage is high stability and no activity.

Description

technical field [0001] The invention relates to a preparation method of visceral and pleural defect repair materials and burn wound coverings, that is, a preparation method especially for preparing visceral damage repairs and burn wound coverings—corpse skin substitutes. technical background [0002] At present, there are no reports of biomaterials for repairing visceral damage. The most ideal cover for burn wounds is cadaver skin. However, the source of cadaver skin is difficult, expensive, and has rejection and transmission of diseases (including hepatitis and AIDS). The danger of pigskin skin is poor in resistance, occupying space and affecting epithelial growth. There is no ideal product for artificial skin at home and abroad. Its main shortcoming of the currently disclosed repairing materials in China is that it cannot be bandaged and compressed after covering the burn wound, otherwise the film is prone to tissue compatibility, that is, the film dissolves and the burn w...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61L27/00
Inventor 刘炳森刘红杰
Owner 刘炳森
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