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Recombined human alkaline fibroblast growth factor gelling agent and process for preparing the same

A fibroblast and growth factor technology, applied in the field of recombinant human basic fibroblast growth factor gel and its preparation, can solve the problem of ineffective recovery of skin accessory function organs, easy to leave scars, and long healing time To achieve the effect of reducing pigmentation, shortening healing time, and reducing scar formation

Inactive Publication Date: 2006-02-15
朗肽生物制药股份有限公司
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Generally, the healing time is longer, and it is easy to leave scars and cause pigmentation, and it is not very effective for the functional recovery of damaged skin accessory organs.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Below in conjunction with a preferred embodiment the present invention will be further described,

[0021] prescription:

[0022] Carbomer 940NF 10g

[0023] Sodium Hyaluronate 2.5g

[0024] Dextran 40 2.5g

[0025] Heparin sodium: bFGF 1:3

[0026] 4% sodium hydroxide 140ml

[0027] 4

[0028] Add water for injection to 1000ml

[0029] A total of 150 sticks

[0030] The specific preparation method is:

[0031] 1. Weigh 10.0g of Carbomer 940NF in a 1L beaker, add 250ml of water for injection to make it swell naturally, add 4% sodium hydroxide after swelling, stir while adding, adjust the pH to 7.0 (about 140ml), and obtain the maximum viscosity Consistency Base (I).

[0032] 2. Weigh 2.5g of sodium hyaluronate into a 500ml beaker, add 400ml of water for injection to make it swell naturally into a gel solution (II).

[0033] 3. Weigh 2.5g of dextran into a 500ml beaker, add 200ml of water for injection, heat to dissolve it into a dext...

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PUM

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Abstract

The invention relates to a recombinant human basic fibroblast growth factor gelling agent and the process for preparation, which comprises recombinant human basic fibroblast growth factor (rh-bFGF) stock solution 0.1-100% (W / W), medicinal auxiliary material 0-99.9% (W / W), the stock solution comprises effective treatment dose of recombinant human basic fibroblast growth factor (rh-bFGF) 0.01-1% (ug / g), NaCl 0.01-20% (W / W), phosphates cushioning liquid 2m Mol - 200m Mol, and right amount of water for injection, the medicinal auxiliary materials can be selected from: carbomer 940NF, sodium hyaluronate, trehalose, mannitol, dextran 40 and sodium heparin.

Description

Technical field: [0001] The invention relates to a recombinant human basic fibroblast growth factor gel and a preparation method thereof. In particular, a recombinant human basic fibroblast growth factor gel suitable for treating burn wounds, fresh wounds and chronic wounds and a preparation method thereof. Background technique: [0002] Wound healing is a complex and highly coordinated process, which can be basically divided into three distinct and interlaced stages: local inflammatory response, cell proliferation and differentiation, and tissue repair and reconstruction. This process involves the interaction and mutual influence of various growth factors and cytokines, and jointly regulates cell migration, proliferation, differentiation, angiogenesis, matrix deposition and tissue modeling. [0003] In the traditional wound repair treatment, measures such as anti-infection, enhanced nutrition of the body and local protection of the wound are used to heal the wound naturall...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/00A61P17/02
Inventor 于忠国曲红艳
Owner 朗肽生物制药股份有限公司
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