Newcastle Disease Viruses and Uses Thereof

Abstract

Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and / or an antagonist of an inhibitory signal of an immune cell.

Description

[0001]This application claims priority to U.S. Provisional Application No. 61 / 782,994, filed on Mar. 14, 2013, which is incorporated by reference herein in its entirety.[0002]This invention was made, in part, with Government support under award numbers 5T32CA009207-35 and HHSN26620070010C from the National Institutes of Health. The Government has certain rights in this invention.1. INTRODUCTION[0003]Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonis...

AI Technical Summary

Benefits of technology

The patent text describes the use of agonists and functional fragments of molecules to treat cancer and related symptoms. Agonists are molecules that bind to a receptor on a cell and trigger signal transduction pathways, while functional fragments of a protein retain its ability to bind to its receptor and induce signaling. The treatment can result in a reduction of cancer symptoms, prevent recurrences, and even inhibit the development of cancer. The patent also describes the use of therapies that combine agonists with other treatments to enhance their effectiveness or prevent cancer progression. Overall, the patent provides a technical solution for treating cancer and related symptoms.

Problems solved by technology

However, the success of naturally-occurring strains of NDV in these clinical trials for advanced human cancers was only marginal (Hotte et al.

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