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Constipation relieving dripping pills with rhubarb and its preparation method

A technology of rhubarb and dripping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc., and can solve problems such as unfavorable improvement of patients’ ability to seek medical treatment, bioavailability of first-pass effect of liver and intestines, and physical hazards of staff. , to achieve the effect of being conducive to labor protection and environmental protection, improving bioavailability, and low labor intensity

Inactive Publication Date: 2005-11-23
北京博智绿洲医药科技有限公司
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] Now with several groups of specific examples, the preparation method of Ye Mudan dripping pills of the present invention will be further described.

[0028] [Group 1: Trials with a single substrate]

[0029] 1. Raw materials: According to [Preparation Method 1], the extract dry powder containing the active pharmaceutical ingredients of the traditional Chinese medicine Rheum officinalis is prepared for subsequent use;

[0030] 2. Substrate: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac;

[0031] 3. Proportion: take g or kg as the unit, by weight, drug extract: matrix = 1:1~1:9;

[0032] 4. Prepare according to the process given in [Preparation Method] 4-7, and you can get rhubarb laxative dropping pills of different specifications.

[0033] [test results]...

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PUM

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Abstract

Disclosed is a dripping pill for treating indigestion, constipation and poor appetite. The objective of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, easy administration, and low price. The drop pill is prepared from rhubarb horsetails as raw material, and medicinal carrying agent as the base material.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has heat-clearing and laxative effect, and is used for the treatment of diseases such as damp-heat stagnation, constipation and damp-heat type loss of appetite, and particularly relates to a kind of oral preparation of the medicine composition prepared from traditional Chinese medicine rhubarb as raw material. Background technique [0002] According to the preparation method given in the national drug standard WS-11058 (ZD-1058)-2002, the rhubarb laxative granule is a kind of laxative with heat-clearing and laxative effect, which is used for damp-heat food stagnation, constipation and damp-heat appetite Oral tablets for the treatment of depression and other diseases have been clinically verified and have definite curative effects. They are commonly used medicines for clinical and family treatment of the above diseases. [0003] The following is the formula, process and brief descripti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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