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Process for preparing medicine-carrying particle containing surface transferrin for glioma target chemical therapy

A glioma targeting and transferrin technology is applied in the field of preparation of drug-loaded targeting microparticles to achieve the effects of reducing systemic side effects, improving chemotherapeutic effects and improving bioavailability

Inactive Publication Date: 2005-10-19
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, transferrin-guided ultraparticle-targeted sustained-release therapy for glioma has not been reported

Method used

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  • Process for preparing medicine-carrying particle containing surface transferrin for glioma target chemical therapy
  • Process for preparing medicine-carrying particle containing surface transferrin for glioma target chemical therapy
  • Process for preparing medicine-carrying particle containing surface transferrin for glioma target chemical therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Dissolve 7 mg of fat-soluble drug carmustine and 35 mg of polylactic acid in 5 ml of acetone under dark conditions to obtain solution A; (2) dissolve 50 mg of transferrin in 25 ml of pH7.2 phosphoric acid In the buffer solution, solution B was obtained; (3) at -4°C, quickly inject solution A into solution B under stirring at a rotating speed of 800 rpm and continue to stir under magnetic conditions until the polylactic acid ultrafine particles solidified; (4 ) Centrifuge the product obtained in step (3) at 10,000 rpm, wash with water, and freeze-dry to obtain polylactic acid ultrafine particles containing transferrin-loaded drugs on the surface.

[0033] The product that the embodiment of the present invention 1 prepares, the ultrafine particle that observes with scanning electron microscope is as figure 1 . Treatment of brain malignant glioma by carotid artery injection: 30 animals were divided into: no treatment group, carotid artery injection of original drug tr...

Embodiment 2

[0035] The polymer carrier used is polyglycolic acid, and the preparation steps are as in Example 1. The product that the embodiment of the present invention 2 prepares, the ultrafine particle that observes with scanning electron microscope such as figure 2 .

Embodiment 3

[0037] The polymer carrier used is polylactic acid-glycolic acid copolymer, and the preparation steps are as in Example 1. The product that the embodiment of the present invention 3 prepares, the ultrafine particle that observes with scanning electron microscope is as image 3 .

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Abstract

The present invention discloses preparation process of medicine-carrying particle containing surface transferrin for glioma targeting chemotherapy, and belongs to the field of preparing technology of medicine-carrying targeting particle. Biodegradable polymer polylactic acid, polyglycolic acid, polycaprolactone or copolymer of lactic acid and glycolic acid and chemotherapeutical medicine carmustine, Adriamycin or taxol are dissolved in acetone, acetonitrile or dimethyl sulfoxide; and the solution is emulsified in solution of transferrin or combined with transferrin chemically after co-dialysis with cholesterol modified glucosan dialdehyde to prepare the medicine-carrying polymer particle containing surface transferrin. This kind of particle may be injected into tumor cavity to make medicine released crossing blood brain barrier and targeting glioma to reach the high inside inhibition of tumor. The present invention has simple preparation process and obvious curative effect.

Description

technical field [0001] The invention relates to a method for preparing drug-loaded microparticles containing transferrin on the surface for glioma targeted chemotherapy, and belongs to the preparation technology of drug-loaded targeted microparticles. Background technique [0002] In the process of disease treatment, in order to improve drug efficacy and reduce toxic side effects, the strategy of drug-directed delivery and target cell-specific treatment has attracted great interest. Ligand-receptor-mediated transport systems have attracted much attention. Under normal circumstances, the combination of ligands and receptors not only enables ligands to be introduced to specific locations, but also can be decomposed by organisms, which are non-toxic and non-immunogenic. [0003] Transferrin is a good ligand, and endocytosis mediated by transferrin and transferrin receptor is one of the most characteristic transport processes in living cells. Transfe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/64A61K47/69A61P35/00
Inventor 原续波蒲佩玉康春生盛京马桂秋郭艳霜
Owner TIANJIN UNIV
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