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Disodium adenosine triphosphate solid composition for injection and its preparing method

A technology of disodium adenosine triphosphate and solid composition, which is applied in the directions of drug combination, medical preparation containing active ingredients, pharmaceutical formula, etc., can solve the problems of easy precipitation, cumbersome procedures, troublesome clinical application, etc., and improve the level of clinical application. And the effect of safety, simple preparation method and convenient clinical application

Inactive Publication Date: 2005-10-19
JINAN PANSHI PHARMA TECH
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  • Summary
  • Abstract
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  • Claims
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Problems solved by technology

Because the injection of adenosine triphosphate disodium and magnesium chloride needs to be mixed and prepared with the injection of adenosine triphosphate disodium (abbreviated as A liquid) and magnesium chloride injection (abbreviated as M liquid) before the clinical application of adenosine triphosphate disodium and magnesium chloride injection, not only the procedures are cumbersome, but also the preparation and application are not stable enough and prone to Precipitation, there are serious hidden dangers, which bring great trouble and unstable factors to clinical application

Method used

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Embodiment Construction

[0017] The present invention will be further described below with examples, and the implementation details of the present invention will be given, but it is not intended to limit the protection scope of the present invention.

[0018] Preparation of adenosine triphosphate disodium 100mg-magnesium chloride 32mg solid composition for injection

[0019] Disodium Adenosine Triphosphate 100g

[0020] Magnesium chloride 32g

[0021] L-Arginine 50g

[0022] Mannitol 150g

[0023] Water for injection 2000ml

[0024] 1000 bottles

[0025] Operation steps: (1) Weigh adenosine triphosphate disodium according to the prescription amount, add 60% of water for injection to dissolve, add 80% of L-arginine, stir to dissolve; (2) weigh the prescription amount of magnesium chloride, add 25% of water for injection , Stir to dissolve; (3) Mix the two solutions evenly. Add mannitol and stir until dissolved, add the remaining L-arginine to control the pH to 4.5~6.5; (4)...

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Abstract

The solid disodium adenosine triphosphate composition for injection consists of disodium adenosine triphosphate 25.0-50.0 wt%, magnesium chloride 8.0-16.0 wt%, sugar alcohol as stabilizer 0.5-50.0 wt% and amino acid as buffering agent 0.5-50.0 wt%, with the weight ratio between disodium adenosine triphosphate and magnesium chloride being 100 to 32. the solid composition has high stability, high solubility, convenient clinical application, and raised clinical application safety of disodium adenosine triphosphate-magnesium chloride injection.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing adenosine triphosphate disodium, and relates to an improved technology for an injection preparation of adenosine triphosphate disodium. Background technique [0002] Adenosine triphosphate disodium magnesium chloride is a high-energy compound that can penetrate the cell membranes of various important organs and increase the level of adenosine triphosphate (also known as adenosine triphosphate disodium, ATP for short) in tissues and cells. In the state of ischemia and hypoxia, it directly supplies energy to cells, thereby improving cell energy metabolism and cell membrane sodium pump mechanism, reducing cell swelling, improving microcirculation disorders, and restoring organ functions. It can improve the permeability of rat liver cell membrane caused by shock, effectively restore the function of ischemic liver cells, improve cell energy metabolism, improve microcirculation disturbance, and...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P1/16A61P9/00A61P25/00A61P31/14A61P39/06
Inventor 王法平孙山李晓翔
Owner JINAN PANSHI PHARMA TECH
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