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Method and composition for treating or preventing catabolism or stimulating anabolism in a mammal undergoing metabolic stress

A technology of mammals and compositions, applied in the direction of drug combinations, metabolic diseases, applications, etc., can solve problems such as uselessness, taste and negative effects of product stability

Inactive Publication Date: 2005-09-28
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such formulas are often useless in reverse catabolism, even though they can sometimes deny net catabolism to some extent
High nutritional density causes several problems, including negative effects on taste and product stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0071] Example 1: In vitro feeding with enteral administration

[0072] Protein: 17en%, Edible carbohydrates: 47en%, Liquid: 36en%.

[0073] The composition contains, per 100ml, 4.0g casein, 0.2Gl-serine, 12.2g maltodextrin, 3.9g vegetable oil, 0.2g lecithin, 0.1g dimethylglycine, minerals and vitamins, recommended according to the invention , folic acid (30 μg), vitamin B6 (0.2 mg), vitamin B12 (0.5 μg).

example 2

[0074] Example 2: High protein product for athletes:

[0075] Powder to dissolve in beverages. Products include: per 100g powder, 94g whey protein concentrate, 1g sarcosine, 1GL-serine, 1gL-leucine, 0.5g xanthan gum resin, 0.3g coloring agent, 0.1g saccharin, 0.1g citric acid .

example 3

[0076] Example 3: Protein for Newborn Babies

[0077] Protein: 12en%, Edible carbohydrates 39en%, Moisture: 49%.

[0078] Powder, containing said per 100ml lysates: 1.4g of whey protein, 0.9g of casein, 0.1g of L-serine;

[0079] Carbohydrates: lactose 6.0g, maltodextrin 1.8g; liquid: butter 1.3g, marine oil mixture 0.05g, vegetable oil 2.4g, lecithin 0.25g.

[0080] Minerals and vitamins recommended according to the present invention, vitamin B12 (hydroxyvitamin B12: 0.3g).

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PUM

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Abstract

The invention is concerned with a method and a composition for treating or preventing catabolism or of stimulating anabolism in a mammal undergoing metabolic stress. The method comprises administering to the mammal a composition containing methyl donors selected from the group consisting of L-serine, methionine, choline, phosphatidyl choline, betaine, dimethylglycine, sarcosine, methylated folates, S-adenosyl methionine, thymidine triphosphate, adenosine triphosphate and optionally methyl acceptors selected from the group consisting of L-glycine, ethanolamine, phosphatidyl ethanolamine, folate, ribose, wherein the total molar amount of methyl donors delivered by the method exceeds the total molar amount of methyl acceptors delivered by the method by at least 0.18 mmol per kg of body weight per day.

Description

Field of Invention [0001] The present invention relates to a method of treating or preventing catabolism and stimulating anabolism when a mammal is subjected to metabolic stress. In particular, the method of the present invention relates to a method comprising administering to a mammal a mixture comprising methyl donors selected from the group consisting of L-serine, methionine acid, phosphatidylcholine, choline, ethidone, dimethylaminoacetic acid, sarcosine, methylfolate, S-adenosylmethionine, thymidine triphosphate, adenosine triphosphate and Their combination, the methyl acceptor can be arbitrarily selected from the following substances: L-glycine, phosphatidylcholine, cholamine, folic acid, ribose and combinations thereof, wherein all of the methyl donors delivered by this method have The molar amount exceeds the molar amount of methyl acceptor delivered by the same method by at least 0.18 millimoles per kilogram of body weight per day. [0002] Another aspect of the inv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/30A23L1/304A23L1/305A23L33/00A23L33/15A61K31/133A61K31/14A61K31/195A61K31/198A61K31/205A61K31/525A61K31/685A61K31/7004A61K31/7072A61K31/7076A61K38/00A61K38/16A61K45/06A61P1/00A61P3/00A61P3/06A61P3/10A61P9/00A61P9/12A61P11/00A61P15/00A61P17/02A61P25/00A61P25/06A61P27/16A61P29/00A61P31/04A61P35/00A61P37/08
CPCA23V2002/00A61K45/06A61K38/16A23L1/302A23L1/3051A23L1/296A23L1/3006A23L1/304A23L1/3056A61K31/195A23L1/293A23L33/30A23L33/40A23L33/115A23L33/15A23L33/16A23L33/175A23L33/19A61P1/00A61P11/00A61P15/00A61P17/02A61P25/00A61P25/06A61P27/16A61P29/00A61P3/00A61P31/04A61P35/00A61P3/06A61P37/08A61P9/00A61P9/12A61P3/10A61K2300/00A23V2250/0642A23V2200/308A23V2200/322A23V2200/324A23V2200/326A23V2200/328
Inventor 罗伯特·约翰·约瑟夫·哈格曼乔治·沃拉恩
Owner NV NUTRICIA
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