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Therapeutic agent for overactive bladder

一种膀胱过度活动、药物的技术，应用在治疗膀胱过度活动的药物领域，能够解决日常生活和个人卫生困难等问题

Inactive Publication Date: 2005-08-24
ASTELLAS PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Urinary incontinence is the classic example of a urine collection disorder and is defined as subjectively demonstrable leakage of urine that makes daily life and personal hygiene difficult

Method used

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  • Therapeutic agent for overactive bladder
  • Therapeutic agent for overactive bladder
  • Therapeutic agent for overactive bladder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 5 g of tamsulosin hydrochloride and 470 g of crystalline cellulose were thoroughly mixed, 500 g of a mixture of 83.3 g of Eudragit L30D-55 (25 g as solid) and water were added thereto, and the mixture was granulated using a high-speed stirring granulator change. The obtained particles are spherical, with a particle diameter of 0.1-1.5 mm, most of which are 0.2-1.0 mm.

[0037] The obtained granules were mixed with talc and magnesium stearate, and filled in capsules to prepare a capsule preparation (containing 0.2 mg of tamsulosin hydrochloride in the capsule).

Embodiment 2-6

[0039] The same method as in Example 1 was used, except that the granules manufactured according to the formula described in Table 1 were made into capsule preparations.

[0040] Example number

Embodiment 7

[0042] 5 g of tamsulosin hydrochloride, 420 g of crystalline cellulose and 50 g of magnesium stearate were thoroughly mixed, a mixture (500 g) of 83.3 g of Eudragit L30D-55 (25 g as solid) and water was added thereto, and the The mixture is kneaded and then granulated with a centrifugal liquid granulator. The obtained particles are spherical, with a particle diameter of 0.1-1.5 mm, most of which are 0.2-1.0 mm.

[0043] The obtained granules were mixed with talc and magnesium stearate, and filled into capsules to manufacture capsule preparations (the capsules contained 0.2 mg of tamsulosin hydrochloride).

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Abstract

A medicinal composition for treatments for overactive bladder which contains tamsulosin or a pharmaceutically acceptable salt thereof as an active ingredient.

Description

field of invention [0001] The invention relates to a medicine, in particular to a medicine for treating overactive bladder. Background technique [0002] Lower urinary tract dysfunction can be broadly divided into urinary collection disorder (increased urinary frequency and urinary incontinence) and urinary disorder (urination difficulty and urinary retention). Urinary incontinence is the classic example of a urine collection disorder and is defined as subjectively demonstrable leakage of urine that makes daily life and personal hygiene difficult. Increased frequency refers to the state of urinating more than normal and is defined as about 2 or more times in the evening and 9 or more times in a 24-hour period. Urinary incontinence can be divided into abdominal pressure incontinence (which occurs when a certain abdominal pressure is reached during a cough or sneeze), impending urinary incontinence (which occurs suddenly and leaks urine before the patient reaches the toilet) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/18A61K31/4725A61K45/06A61P13/00A61P13/02A61P13/10A61P43/00
CPCA61K45/06A61K31/18A61K31/4725A61P13/00A61P13/02A61P13/10A61P43/00A61K2300/00
Inventor R·冯梅斯特恩N·J·维瑟梶井宽滝口啓行
Owner ASTELLAS PHARMA INC
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