Indirubin phosphatide compound and its preparation method
A technology of indirubin phospholipid and compound, which is applied in the field of indirubin phospholipid compound and its industrializable preparation, can solve the problems of poor water-solubility and fat-solubility, incomplete oral absorption, large gastrointestinal irritation, etc. Improve absorption, enhance pharmacological action and curative effect, and improve bioavailability
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Embodiment 1
[0019] Example 1: Take 5 mg of indirubin, dissolve it in 25 ml of ethyl acetate to obtain a purple-red clear liquid, add soybean lecithin (Shanghai Taiwei Pharmaceutical Co., Ltd., injection grade, batch number 040108, containing 75-80% of phospholipid) 45 mg (Indirubin 5mg: phospholipid 45mg is equivalent to a molar ratio of 1:3), stirred until the solution became clear, heated at 80°C while shaking and reacted for 2 hours, removed the reaction solvent under reduced pressure, and dried in a conventional low-temperature vacuum to obtain a purple-red semi-solid compound things. Get phospholipids, indirubin and indirubin phospholipid complex for DSC analysis (attached Figure 1-3 ), the result is that indirubin has a phase transition point at 353.0°C, and the phase transition point of the compound is increased, and the phase transition point of indirubin is no longer visible at 353.0°C, which proves the formation of "indirubin phospholipid complex" .
[0020] The solubility of...
Embodiment 2
[0021] Example 2: Weigh 10 mg of indirubin, dissolve it in 50 ml of tetrahydrofuran to obtain a purple-red clear liquid, add 90 mg of soybean lecithin, stir until the solution is clear, shake and react for 2 hours while heating at 30 ° C, remove the reaction solvent under reduced pressure, and vacuum at low temperature After drying, a purple-red semi-solid compound was obtained.
Embodiment 3
[0022]Example 3: Weigh 10 mg of indirubin, dissolve it in 50 ml of hot acetone to obtain a purple-red clear liquid, add 90 mg of egg yolk phospholipid, stir until the solution is clear, and shake the reaction for 3 hours while heating at 60°C to keep warm, remove the reaction solvent under reduced pressure, and lower the temperature After vacuum drying, a purple-red semisolid compound was obtained.
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