Process for preparing broad spectrum antimicrobial triclosan

A production process and technology for triclosan products, applied in ether preparation, organic chemistry and other directions, can solve the problems of complex steps and high process costs, and achieve the effects of reducing production costs, reducing extraction times, and excellent suppressing and killing ability.

Inactive Publication Date: 2005-06-22
季文彬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is: because in the prior art, what preparation triclosan adopts is the loaded down with trivial details process route that extracts with tetrachlorethylene seven times, process cost is high, and steps are complicated, the purpose of the present invention is to provide a kind of The production process of triclosan, a broad-spectrum antibacterial agent, includes using 2,5-dichloronitrobenzene and 2,4-dichlorophenol as raw materials to carry out etherification reaction, nitro reduction, diazotization hydrolysis reaction, and, After the hydrolysis reaction, the triclosan product should be purified with toluene

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the bacteriostasis of the triclosan that the method of the present invention obtains

[0012] 1. The inhibitory concentration (MIC) of triclosan to bacteria

[0013] in the agar nutrient medium. Triclosan has a good ability to inhibit and kill a wide range of Gram-positive and negative bacteria at low concentrations.

[0014] 2. Action against antibiotic bacteria

[0015] Experiments have shown that triclosan is equally effective against antibiotic-resistant bacteria as well as non-antibiotic-resistant bacteria.

[0016] 3. Minimum inhibitory concentration (MIC) for fungi and yeast

[0017] Triclosan has excellent inhibitory and killing abilities to both fungi and yeast.

Embodiment 2

[0018] Embodiment 2: Toxicology and ecological research of triclosan obtained in the present invention

[0019] The inventor entrusts Shanghai Pesticide Research Office to show through a large number of tests that triclosan has good compatibility with human skin, and the long-term animal toxicology test has also proved that triclosan is the best in the recommended range of use and dosage. Safe and efficient broad-spectrum antibacterial agent.

[0020] 1. Toxicological research on "Triclosan" product

[0021] (1) Oral, dermal and inhalation acute toxicity

[0022] [Oral toxicity] Triclosan has basically no detectable toxicity to rats, mice and dogs after single administration when administered by gastric tube.

[0023] Half lethal dose LD50 rat: 4300mg / kg

[0024] Mice: 4500mg / kg

[0025] Dog: 5000mg / kg

[0026] [Inhalation Toxicity] LD50 Rat: 0.15mg / 19 (Unable to reach a higher concentration)

[0027] [Skin ...

Embodiment 3

[0050] Example 3: Ecological Research on Triclosan Products

[0051] Biodegradability [laboratory determined]

[0052] Triclosan was hardly degraded by activated sludge in the laboratory wastewater treatment pond. Triclosan content in synthetic wastewater up to 2ppm will not reduce the efficiency of the treatment tank. Triclosan can be carried away by adsorption on activated sludge.

[0053] BOD = 0 mg / g oxygen

[0054] COD=1116 mg / g oxygen

[0055] Photodegradability [laboratory determination]

[0056] Triclosan dissolved in wastewater is rapidly broken down by sunlight. In summer, its half-life is about 3 hours. More than 90% of the active ingredients are decomposed by direct summer sunlight.

[0057] Soil Infiltration [Laboratory Determination]

[0058] Triclosan absorbed in sludge used as agricultural fertilizer is not carried into groundwater by rainwater or by percolation. Triclosan only penetrates the top soil.

[0059] [Outdoor experiment] The...

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Abstract

The invention provides a process for preparing broad spectrum antimicrobial triclosan, which consists of using 2,5-dichloronitrobenzene and 2,4-dichlorophenol as raw material, carrying out in sequence etherification reaction, nitro group deacidizing, diazotization hydrolytic reaction, purifying with toluene for three times. The invention can decrease extraction frequency and reduce production costs substantially.

Description

technical field [0001] The invention belongs to the field of chemical industry and relates to a preparation method of an antibacterial agent. Furthermore, the invention relates to a production process of a broad-spectrum antibacterial agent triclosan. Background technique [0002] Triclosan is a safe and efficient broad-spectrum antibacterial agent, widely used in daily chemical, medical and textile industries, replacing other antibacterial disinfectants. The chemical name of triclosan is 2,4,4-trichloro-2-hydroxydiphenyl ether, and its molecular formula is C 12 h 7 Cl 3 o 2 , with a molecular weight of 289.5. Triclosan is slightly soluble in water, has moderate solubility in dilute alkali, and has high solubility in many organic solvents. It can be made into a transparent concentrated liquid product after dissolving in water-soluble solvents or surfactants. [0003] Triclosan has efficient killing and inhibiting effects on Gram-positive bacteria, Gram-negative bacteria...

Claims

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Application Information

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IPC IPC(8): C07C41/01C07C43/295
Inventor 季文彬
Owner 季文彬
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