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Qinbaohong solution preparation used for inhalation and preparation method thereof

A kind of preparation technology of Qinbahong, which is applied in the field of pharmacy to achieve the effects of low production cost, low dosage and high stability

Inactive Publication Date: 2019-08-06
BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, how to prepare a safe and effective inhalation Qinbaohong solution preparation with Manshanhong, Baomazipi and Scutellaria baicalensis as raw materials has not been reported yet.

Method used

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  • Qinbaohong solution preparation used for inhalation and preparation method thereof
  • Qinbaohong solution preparation used for inhalation and preparation method thereof
  • Qinbaohong solution preparation used for inhalation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Qin Baohong Inhalation Solution

[0038]

[0039] (1) Take Manshanhong, add 10 times the amount of water for the first time, distill for 6 hours, collect the volatile oil and extract for use, add 10 times the amount of water to the medicine residue, decoct for 1.5 hours, add 10 times the amount of water for the second time, and decoct 1.5h, filter, combine the filtrate, concentrate, add ethanol to 80% alcohol content, stir, let stand for more than 12h, filter, recover ethanol to 1ml containing 4g crude drug, add water to 1ml containing 0.5g crude drug, and have been processed After washing a good macroporous resin column with water, it is eluted with 40% ethanol, the eluate is collected, the ethanol is recovered, and concentrated to dryness to obtain the active ingredient of Manshan Red

[0040] (2) Decoction with water for two times, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, decoct for 2 hours, filter...

Embodiment 2

[0044]

[0045] (1) Take Manshanhong, add 10 times the amount of water for the first time, distill for 6 hours, collect the volatile oil and extract for use, add 10 times the amount of water to the medicine residue, decoct for 1.5 hours, add 10 times the amount of water for the second time, and decoct 1.5h, filter, combine the filtrate, concentrate, add ethanol to 80% alcohol content, stir, let stand for more than 12h, filter, recover ethanol to 1ml containing 4g crude drug, add water to 1ml containing 0.5g crude drug, and have been processed After washing a good macroporous resin column with water, it is eluted with 40% ethanol, the eluate is collected, the ethanol is recovered, and concentrated to dryness to obtain the active ingredient of Manshanhong;

[0046] (2) Take the pumila peel and add water to decoc 2 times, add 10 times the amount of water for the first time, decoc 2h, and add 8 times the amount of water for the second time, decoc 2h, filter, combine the filtrate, conc...

Embodiment 3

[0050]

[0051] (1) Take Manshanhong, add 10 times the amount of water for the first time, distill for 6 hours, collect the volatile oil and extract for use, add 10 times the amount of water to the medicine residue, decoct for 1.5 hours, add 10 times the amount of water for the second time, and decoct 1.5h, filter, combine the filtrate, concentrate, add ethanol to 80% alcohol content, stir, let stand for more than 12h, filter, recover ethanol to 1ml containing 4g crude drug, add water to 1ml containing 0.5g crude drug, and have been processed After washing a good macroporous resin column with water, it is eluted with 40% ethanol, the eluate is collected, the ethanol is recovered, and concentrated to dryness to obtain the active ingredient of Manshanhong;

[0052] (2) Take the pumila peel and add water to decoc 2 times, add 10 times the amount of water for the first time, decoc 2h, and add 8 times the amount of water for the second time, decoc 2h, filter, combine the filtrate, conc...

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Abstract

The invention belongs to the field of a preparation, and particularly relates to a Qinbaohong solution preparation used for inhalation and a preparation method thereof. The Qinbaohong solution preparation comprises an active ingredient, an auxiliary agent and a solvent; the Qinbaohong solution preparation is prepared by the active ingredients extracted from effective components of Chinese traditional medicine Rhododendron dahuricum, manchurian lilac bark and radix scutellariae. The Qinbaohong solution preparation is safe, effective and high in bioavailability, and has the advantages of low usage dosage, quick onset, good curative effect and no other side effects.

Description

Technical field [0001] The invention belongs to the field of pharmaceutics, and specifically relates to a Qin Baohong solution preparation for inhalation and a preparation method thereof. Background technique [0002] "Qin Bao Hong" is a prescription composed of three Chinese medicines: Manshan Red, Baoma Zipi, and Scutellaria baicalensis Georgi. It has the effects of clearing away heat and reducing phlegm, relieving cough and relieving asthma. Among them, the terpenes contained in the aqueous solution of the leaves of Manshanhong and the volatile oil have obvious antitussive and expectorant effects. Rhododendron has good expectorant effects, and Rhododendron has good antitussive effects; the medicinal part of the bark of pum is the trunk In the bark of the branches, the effective ingredients with expectorant effects are acid phenols and flavonoids, the effective ingredients for anti-asthmatic effects are terpenes; the main effective ingredient in Scutellaria baicalensis is baica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63A61K9/72A61K9/08A61P11/00A61P11/14A61P11/06
CPCA61K9/0078A61K9/08A61K36/45A61K36/539A61K36/63A61K47/02A61K47/26A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 张保献胡杰
Owner BEIJING INCREASE INNOVATIVE DRUG RESEARCH CO LTD
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