Magnetic microparticle operation controller

Abstract

A magnetic particle controller relates to function device making use of magnetic force to control magnetic ball, cell biological molecule and other particles, comprising plate micro coil integrated on front and reverse sides of one substrate, magnetic micro magnetic core and magnetic tip. When electric current passing through the plate micro coil, electromagnetic field is created near it and magnetic particles near the magnetic micro tip will be absorbed onto it, when the electricity is cur off, the particles will be released since the magnetic field force has disappeared. The method of making plate micro coil only relates to a modeling of photoresist and a copper electroplating course , the process is simple and convenient. Including magnetic ball, cell biological molecule and other particles as objections , the invention can be used alone and also as a part to integrate a micro complete analysis system., with the functions of controlling a single particle, counting a single particle values, screening or separating particle mixture, it can be applied in the fields such as cell biology, immunology analysis, micro fluid research and millimicron technology.

Description

technical field [0001] The invention relates to a magnetic particle manipulator, in particular to a functional device for manipulating particles such as magnetic beads, cells, and biomolecules by using magnetic force. Background technique [0002] The micro-total analysis system is also called lab-on-a-chip, which integrates three steps of sample preparation, biochemical reaction and result detection on a single device, and can perform specific analysis functions. As a highly integrated system, the micro-total analysis system consists of many components, including microfluidic channels, micropumps, microvalves, particle manipulators, etc. Among them, the particle manipulator can manipulate magnetic beads, cells, biomolecules and other particles with sizes ranging from microns to nanometers in a microfluidic environment. [0003] Dielectrophoresis, electroosmosis, ultrasound, magnetism and other physical phenomena can be used to manipulate particles. Among them, using a mag...

AI Technical Summary

Problems solved by technology

However, the processing of this micro-solenoid coil requires two steps of photoresist modeling, two copper electroplating and one electroplating of permeable alloy. The processing technology is complicated and the processing cost is relatively high.

In addition, the structure of the micro-solenoid coil is not compact enough. When it is integrated into a micro-total analysis system with a complex structure (such as a system containing dense microfluidic channels) as a component, it will bring serious problems to the layout and design of the entire system. Therefore, it is difficult for the particle manipulation device using the micro-solenoid coil as the excitation coil to be widely used in the micro-total analysis system.

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