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Globeflower oral disintegration tablet and its preparing method

A technology of orally disintegrating tablets and nasturtium, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, and can solve problems such as high prices, increased production costs, and impacts on production costs

Inactive Publication Date: 2005-03-02
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the orally disintegrating tablets made of these excipients have relatively strict environmental requirements during production, storage and transportation, and special packaging, sealing caps, desiccant bags, etc. must be used, which will have a great impact on production costs.
Moreover, the above-mentioned disintegrants are all synthesized through a chemical process, and the price is relatively high. For orally disintegrating tablets with a relatively large content of excipients, it will lead to increased production costs and further increase the economic burden on patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0122] (1) The raw medicinal material is: 400g of nasturtium;

[0123] (2) Pulverize the medicinal materials, extract 4 times with 12 times the amount of 50% ethanol, 3 hours each time; combine the extracts and filter, recycle the ethanol from the filtrate until it has no alcohol smell, and use 3 times the amount of macroporous adsorption resin on the concentrated solution Wash with a certain amount of water, then elute with 80% ethanol, collect the ethanol eluate, concentrate, dry, and pulverize to obtain 40g of extract;

[0124] (3) The preparation prescription is:

[0125] Extract 40g

[0126] Nano microcrystalline cellulose 50g

[0127] Erythritol 20g

[0128] Chitin 25g

[0129] Mannitol 10g

[0130] Magnesium Stearate 5g

[0131] (4) The above-mentioned extract was mixed with pharmaceutical excipients, granulated, dried, sized, compressed, inspected, and packaged to obtain 400...

Embodiment 2

[0133] (1) The raw medicinal material is: 400g of nasturtium;

[0134] (2) Pulverize the medicinal materials, extract 2 times with 6 times the amount of 90% ethanol, 1 hour each time; combine the extracts and filter, recycle the ethanol from the filtrate until it has no alcohol smell, and use 6 times the amount of macroporous adsorption resin on the concentrated solution Wash with a certain amount of water, then elute with 40% ethanol, collect the ethanol eluate, concentrate, dry, and pulverize to obtain 10 g of extract;

[0135] (3) The preparation prescription is:

[0136] Extract 10g

[0137] Microcrystalline Cellulose 127.5g

[0138] Erythritol 10.5g

[0139] Sodium carboxymethyl starch 4.5g

[0140] Talc powder 0.5g

[0141] (4) The above-mentioned extract was mixed with pharmaceutical excipients, granulated, dried, sized, compressed, inspected, and packaged to obtain 400 orally disintegrating...

Embodiment 3

[0143] (1) The raw medicinal material is: 400g of nasturtium;

[0144] (2) Pulverize the medicinal material, extract 3 times with 8 times the amount of 70% ethanol, 2 hours each time; combine the extracts and filter, recycle the ethanol from the filtrate until it has no alcohol smell, and use 4 times the amount of macroporous adsorption resin on the concentrated solution first amount of water, then eluted with 60% ethanol, collected the ethanol eluate, concentrated, dried, and pulverized to obtain 15.8 g of the extract;

[0145] (3) The preparation prescription is:

[0146] Extract 15.8g

[0147] Nano microcrystalline cellulose 108g

[0148] Erythritol 7.2g

[0149] Cross-linked sodium carboxymethyl starch 16.8g

[0150] Stevioside 0.5g

[0151]Magnesium Lauryl Sulfate 2.5g

[0152] (4) The above-mentioned extract was mixed with pharmaceutical excipients, granulated, dried, sized, compressed, insp...

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PUM

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Abstract

The oral disintegrated globeflower tablet for laryngopathy consists of globeflower extract and medicinal supplementary material. The preparation process is also disclosed. One kind of composite disintegrating agent is also disclosed, which consists of erythritol in 30-70 wt% and chitin or available common disintegrating agent. Compared with available technology, the present invention has shorter disintegration time, higher bioavailability, more powerful pharmacological effect and higher stability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to an orally disintegrating tablet of Trollius chinensis and a preparation method thereof. technical background [0002] The nasturtium is the dried flower of the ranunculaceae plant nasturtium and the Asian nasturtium. It has the effect of reducing heat and detoxification, and the active ingredients are flavonoids. It has strong antibacterial effect on Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus albus, Flexneri bacillus, Escherichia coli, typhoid bacillus, paratyphoid bacillus, Proteus, Shigella dysenteriae. At present, the preparations using Trollius as raw materials include Trollius Granules, Trollius Granules (WS3-75(X-65)-94(Z)), Trollius Tablets (WS3-B-3258-98), Trollius Oral Liquid (WS3-B-3257-98), Golden Lotus Capsules (WS-11475(ZD-1475)-2002). The preparation method is that the water extract or extract of the nasturtium...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P31/04
Inventor 张晴龙
Owner 张晴龙
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