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Sinlmenine hydrochloride plaster and its preparation method

A technology of sinomenine hydrochloride and poultice, applied in the field of medicine, can solve the problems of short biological half-life and easy decomposition, and achieve the effects of enhancing analgesia, improving compliance, and reducing the fluctuation of blood drug concentration

Inactive Publication Date: 2004-12-29
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its short biological half-life, and side effects such as skin rash caused by the release of histamine, it is easy to decompose under alkaline conditions, so it is necessary to conduct pharmaceutical research to make up for the above defects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Sinomenine Hydrochloride 2g

[0012] Glycerin 5g

[0013] Polyacrylic acid (Carbopol Ultrez 10) 0.4g

[0014] Sodium polyacrylate (Carborit 7S) 0.8g

[0015] Sodium polyacrylate (Carborit K39) 0.8g

[0016] Tartaric acid 0.06g

[0017] Aluminum hydroxide 0.04g

[0018] Deionized water 10g

[0019] Skin penetration enhancer 0.5g

[0020] Total 19.6g

[0021] Preparation:

[0022] 1. Disperse the polymer in glycerin to obtain phase A;

[0023] 2. Mix aluminum hydroxide and tartaric acid in a small amount of deionized water to obtain phase B;

[0024] 3. Add the transdermal enhancer and drug into sufficient deionized water to obtain Phase C;

[0025] 4. Mix phase A and phase B, disperse in phase C under stirring, spread evenly on non-woven fabric, and cover with anti-sticking layer to obtain.

[0026] The above dosage can prepare 5 patches of cataplasm of 5cm×5cm, each patch contains 400mg of sinomenine hydrochloride, and the water content is 51%.

Embodiment 2

[0028] Sinomenine Hydrochloride 2g

[0029] Glycerin 5g

[0030] Polyacrylic acid (Carbopol Ultrez 10) 0.8g

[0031] Sodium polyacrylate (Carborit 7S) 1.0g

[0032] Sodium polyacrylate (Carborit K39) 0.2g

[0033] Tartaric acid 0.05g

[0034] Aluminum hydroxide 0.03g

[0035] Deionized water 10g

[0036] Skin penetration enhancer 0.5g

[0037] Total 19.58g

[0038] The preparation method is the same as described in the above example.

[0039] The above dosage can prepare 5 patches of cataplasm of 5cm×5cm, each patch contains 400mg of sinomenine hydrochloride, and the water content is 51%.

Embodiment 3

[0041] Sinomenine Hydrochloride 2g

[0042] Glycerin 5g

[0043] Polyacrylic acid (Carbopol Ultrez 10) 1.2g

[0044] Sodium polyacrylate (Carborit 7S) 0.6g

[0045] Sodium polyacrylate (Carborit K39) 0.2g

[0046] Kaolin 1g

[0047] Tartaric acid 0.06g

[0048] Aluminum hydroxide 0.04g

[0049] Deionized water 9g

[0050] Skin penetration enhancer 0.5g

[0051] Total 19.6g

[0052] The preparation method is the same as described in the above example.

[0053] The above dosage can prepare 5 patches of cataplasm of 5 cm×5 cm, each patch contains 400 mg of sinomenine hydrochloride, and the water content is 45.9%.

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PUM

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Abstract

The coculine hydrochloride cataplasma with raised patient compliance includes coculine hydrochloride as medicine component; matrix comprising water soluble polymer skeleton, stuffing, cross-linking agent, cross-linking regulator, humectant and transdermal promoter; and non-woven fabric as lining layer. The preparation process includes dispersing water soluble polymer in glycerin to obtain phase A; mixing cross-linking agent, cross-linking regulator and small amount of deionized water to obtain phase B; adding transdermal promoter, medicine and sufficient deionized water to obtain phase C; mixing phase an and phase B and adding gradually phase C to obtain mixture; painting the mixture onto the lining layer and covering with anti-sticking layer. The present invention has good skin hydrolyzing effect, proper skin affinity, no pain produced during taking off, no irritation on skin and obvious slowly releasing effect.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically a new dosage form of anti-inflammatory and immunosuppressant sinomenine hydrochloride-sinomenine hydrochloride cataplasm and its preparation method Background technique: [0002] Sinomenine hydrochloric (Sinomenine hydrochloric) is the medicinal hydrochloride of sinomenine, an alkaloid monomer extracted from the traditional Chinese medicine Qingfengteng. Pharmacological effects, tablets, injections, and capsules have been used clinically to treat various rheumatic diseases such as rheumatoid arthritis and arrhythmia, and have achieved good curative effects. Due to its short biological half-life, side effects such as skin rash due to the release of histamine, and easy decomposition under alkaline conditions, it is necessary to conduct pharmaceutical research to make up for the above defects. Invention content: [0003] The object of the present invention is to provide a sinomenin...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/473
Inventor 潘卫三王磊
Owner SHENYANG PHARMA UNIVERSITY
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