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Alfuzosin dripping pills and its preparation

A technology of alfuzosin and dripping method, which is applied in the field of alfuzosin dropping pills and its preparation, and can solve the problems of affecting the therapeutic effect of alfuzosin, long disintegration time of alfuzosin tablets, and large proportion of excipients and other problems, to achieve the effect of convenient carrying and taking, good compliance, and reduced amount of auxiliary materials

Inactive Publication Date: 2004-11-17
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Alfuzosin tablets take a long time to disintegrate, have poor absorption, low bioavailability, and a large proportion of excipients. Children, the elderly, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of alfuzosin. to play

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] prescription:

[0021] Alfuzosin 2.5g

[0022] Macrogol 6000 18g

[0023] Makes 1000 capsules

[0024] Preparation method: Take the alfuzosin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 2

[0026] prescription:

[0027] Alfuzosin 2.5g

[0028] Macrogol 4000 18g

[0029] Makes 1000 capsules

[0030] Preparation method: Take the alfuzosin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone oil as a coolant, make pellets by drop method, and dry. have to.

example 3

[0032] prescription:

[0033] Alfuzosin 2.5g

[0034] Macrogol 6000 6g

[0035] Macrogol 4000 12g

[0036] Makes 1000 capsules

[0037] Preparation method: Take alfuzosin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone as coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0038] 4. Example 4

[0039] prescription:

[0040] Alfuzosin 2.5g

[0041] Glyceryl monostearate 18g

[0042] Makes 1000 capsules

[0043] Preparation method: Take the alfuzosin fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as the coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

The invention relates to an Alfuzosin drop pill prepared by utilizing ultramicro disintegration and drop pill manufacturing process, which has the advantages of improving collapse and dissolving speed, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, and easiness in carrying and use. It has good compliance, thus is especially suitable for children, the elderly, bedridden patients and dysphagia patients.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to alfuzosin dripping pills and a preparation method thereof. Background technique [0002] Alfuzosin (Alfuzosin) is a derivative of quinazoline, which can competitively and highly selectively antagonize the α-α protein present in the prostate, prostate capsule, proximal urethra and bladder bottom smooth muscle 1 Adrenergic receptors, which in turn reduce the tone of the genitourinary tract, leading to amelioration of symptoms associated with decreased urethral tone, resistance, and pressure, bladder outlet obstruction, and bladder instability associated with prostatic hypertrophy. It has little effect on blood pressure and is suitable for mild and moderate benign prostatic hypertrophy, especially for patients with obvious obstruction symptoms. [0003] Alfuzosin tablets take a long time to disintegrate, have poor absorption, low bioavailability, and ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/517A61P13/08
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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