Anticancer Chinese traditional extracts and preparation process and application thereof

A technology of anti-cancer activity and extract, applied in the direction of medical preparations containing active ingredients, drug delivery, drug combination, etc., can solve the problems of increasing patient pain, improper application, and patients' susceptibility to infectious diseases, so as to ensure safety Sexuality and effectiveness, reducing toxic and side effects, good anticancer effect

Inactive Publication Date: 2004-11-10
李文军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many anti-tumor chemical drugs, such as cyclophosphamide, 5-fluorouracil, cytarabine, bleomycin, vinblastine, harringtonine, cisplatin, carboplatin, etc., but they not only It only kills local cancer cells, but also kills white blood cells in the bone marrow, causing leukopenia, which makes patients susceptible to infectious diseases. Chemotherapy drugs can also affect the ability of bone marrow hematopoietic cells and platelet production, causing patients to encounter very slight damage , can also cause bleeding or internal bleeding. In addition, secondary tumors caused by chemotherapy may appear many years later; existing chemotherapy drugs still have the following side effects, such as: nausea, vomiting, anorexia, hair loss, stomatitis, allergies Sexual rash, liver function damage and decreased body resistance, prone to secondary infections, etc. Some chemotherapy drugs can also damage the cells of the heart, kidney, bladder, lung and nervous system, etc., all of which will increase the pain of the patient. Affect the quality of life of patients, so its application has great limitations
[0004] Existing traditional Chinese medicines are divided into two categories when they are used for tumor treatment. One category is therapeutic drugs, such as some compound prescriptions, but there are disadvantages such as unclear active ingredients, unclear mechanism, and low potency, and some compound prescriptions even contain huge toxic ingredients. , such as arsenic, angelica, mylabris, improper application, easy to produce serious side effects, and even life-threatening; and traditional Chinese medicine anti-tumor polysaccharides such as lentinan, ginseng polysaccharides, etc. Although the toxicity is low, but because they are macromolecular foreign substances , entering the blood is prone to hypersensitivity reactions, resulting in serious consequences, ginsenoside Rg3 and other anti-angiogenic preparations can also inhibit the neovascularization of normal blood vessels
Another type of tumor treatment drug is tumor adjuvant drug, which is used to reduce the side effects of radiotherapy and chemotherapy, but it does not have the effect of directly treating tumors.
So far, there has been no report that the saponin-containing extract of the romoaceae plant Agnaceae has anticancer effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Take 100kg of Wuguteng, add 800kg of water, boil and extract for 1 hour, filter, and reserve the filtrate, add 700kg of water to the medicine residue, boil and extract for 1 hour, filter, combine the two filtrates, and concentrate the combined filtrate to a relative density of 1.08 The thin extract is passed through D101 macroporous adsorption resin, first eluted with water until colorless, this water eluate is discarded, and then eluted with 85% ethanol to colorless, collect the 85% ethanol Eluent, the 85% ethanol eluate after the recovery of ethanol is concentrated into a thick extract with a relative density of 1.11, and the thick extract is spray-dried to obtain a Saponin extract containing 50% of saponin, that is, the saponin content It is 50% Chinese medicine extract with anticancer activity.

Embodiment 2

[0103] Take 100kg of Wuguteng, add 900kg of water, boil for 2 hours, filter, and use the filtrate for use, add 900kg of water to the medicine residue, boil for 1 hour, filter, combine the two filtrates, concentrate to a relative density of 1.05, add ethanol to the ethanol content It is 40%, let stand for 18 hours, take the supernatant, recover ethanol from the supernatant into a dilute extract with a relative density of 1.02, pass the dilute extract through D201 macroporous adsorption resin, and eluted with 15% ethanol Discard the 15% ethanol eluate until it is colorless, and then eluted with 60% ethanol until it is colorless, collect the 60% ethanol eluate, and concentrate the 60% ethanol eluate after the ethanol recovery to a relative density The thick extract is 1.10, and the thick extract is dried under reduced pressure to obtain an extract of Wu Guteng containing 40% of saponins, that is, an extract of traditional Chinese medicine with anticancer activity with 40% of saponins...

Embodiment 3

[0105] Take 100kg of Wuguteng, add 1000kg of water, boil for 2 hours, filter, and reserve the filtrate, add 900kg of water to the medicine residue, boil for 1 hour, filter, and reserve the filtrate, add 900kg of water to the medicine residue, boil and extract for 1 hour, filter , Combine the three filtrates, concentrate to a relative density of 1.05, add ethanol to 95% ethanol content, let stand for 24 hours, take the supernatant, recover the supernatant ethanol into a thin extract with a relative density of 1.05, dilute this The extract is passed through D201 macroporous adsorption resin, first eluted with 20% ethanol until colorless, discarded the 20% ethanol eluate, and then eluted with 50% ethanol until colorless, collect the 50% ethanol eluate , The 50% ethanol eluate after the recovery of ethanol is concentrated into a thick extract with a relative density of 1.09, and the thick extract is dried under reduced pressure to obtain a saponins 70% extract of Wuguteng, that is, th...

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PUM

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Abstract

The invention discloses a prepared traditional Chinese medicinal preparation having anticancer reactivity, which is an extraction containing saponin prepared from Marsdenia tenacissima, a traditional Chinese medicinal Asclepiadaceae plant through refining. The invention also discloses the process for preparing the traditional Chinese medicinal preparation having anticancer reactivity and its use.

Description

Technical field [0001] The present invention relates to a traditional Chinese medicine extract, more specifically, the present invention relates to an effective part extracted from the traditional Chinese medicine Wu Guteng. The invention also relates to a preparation method and application of the traditional Chinese medicine extract. Background technique [0002] With the advancement of medicine, general infectious diseases are gradually controlled, and malignant tumors, cancer, have become one of the main diseases that are common and seriously threaten human life and quality of life. Since 1996, there have been more than 10 million newly diagnosed cancer patients worldwide each year, and more than 7 million deaths. By the end of 1999, the total number of cancer patients worldwide had exceeded 40 million. The incidence of tumors in my country is also alarming, and it has become the second leading cause of death in our country. According to statistics from the Ministry of Health,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61P35/00
Inventor 李文军
Owner 李文军
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