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Method for preparing novel anti-cancer medicine

A new drug and fresh technology, applied in the field of anti-tumor drugs, to relieve cancer symptoms, inhibit tumor growth, and improve the quality of life of patients

Inactive Publication Date: 2004-09-15
张仕状
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Geckos belong to the genus Gecko of the family Lizardidae, reptiles, phylum lizards, also known as Tianlong, Shougong, etc. Traditional Chinese medicines are mostly ground into medicines with their dried insect bodies, and are used for the treatment of tumors and tuberculosis together with other medicines. For example, the publication number is CN1279988A Gecko (gecko) is contained in the raw materials of the patent application for "a drug for treating tumors", but there is no report on the extraction of active ingredients of anticancer drugs from gecko.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Remove the viscera of the fresh gecko, wash it with distilled water, put it in a blender and grind it, soak it in acidic ethanol solution for 12 hours, extract it by percolation or cold soaking method, recover the ethanol to get the extract, add enough distilled water to dilute, filter and remove The precipitated impurities are alkalized, and the filtered filtrate is extracted twice with chloroform, and the extract is placed in a refrigerator at a temperature of 3°C for 24 hours, precipitated and filtered to remove impurities, and the filtrate is placed in a water bath at 70°C with a thin film evaporator Concentrate, dry at a constant temperature at 40°C after concentration, and crush through a 120-mesh sieve to obtain the active ingredient of the drug or use CO 2 The active ingredient of the drug is obtained by supercritical extraction, which is dissolved in methanol for use; lecithin and cholesterol (the weight ratio of the two is 1: 1) are dissolved in absolute ethano...

Embodiment 2

[0037] Clean the fresh gecko with distilled water, put it in a blender, and then soak it in acidic ethanol solution for 24 hours. After recovering the ethanol, add enough distilled water to dilute, filter to remove the precipitated lipid impurities, alkalinize the water, and use the filtrate Extract twice with chloroform, place the extract in a refrigerator at 5°C for 36 hours, precipitate and filter to remove impurities, concentrate the filtrate in a water bath at 60°C with a thin-film evaporator, and dry the concentrate at a constant temperature at 50°C dry, crushed through a 120-mesh sieve to obtain the active ingredient of the drug (or use CO 2 supercritical extraction method to obtain the active ingredient of medicine), be dissolved in methanol for use; take lecithin, phosphoric acid ester and cholesterol according to the ratio of 1:1 of the total amount and the active ingredient of the medicine and dissolve them in absolute ethanol, and the three components The weight ra...

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Abstract

The preparation method of anticancer new medicine by using fresh house lizard as raw material includes the following steps: dresing fresh house lizard and cleaning it with distilled water, crushing and soaking it in acidic ethyl alcohol solution, extracting by using percolation method or condensation method, recovering ethyl alcohol to obtain extract, diluting by adding distilled water, filtering to remove impurity, alkalifying filtrate, filtering and using chloroform to extract the filtrate at twice, storing the extract in cold storage tank for 24-26 hr at 2-5 deg.C, precipitating, separating out and filtering out impurity, concentrating and drying filtrate, pulverizing and sieving with 120 meshes to obtain medicinal active component, dissolving it in methyl alcohol for stand-by; dissolving lecithin or / and phosphate or / and cholesterol in anhydrous ethyl alcohol, mixing above-mentioned two solutions, emulsifying, adding calcium ion and EDTA, removing organic solvent so as to make it into phosphatide film large monolayer liposome, then it can be made into the required dosage form.

Description

Technical field [0001] The invention relates to the technical field of antitumor drugs, in particular to the preparation of an anticancer drug which extracts active ingredients from animals. Background technique [0002] Cancer chemotherapy is one of the three pillars of cancer treatment. Although there are many anticancer drugs and clinical chemotherapy has achieved remarkable results, there are still many common tumors such as non-small cell lung cancer, gastrointestinal tumors, primary tumors, etc. Hepatocellular carcinoma, malignant melanoma and other chemotherapy effects are not satisfactory. Moreover, most of these anticancer drugs have serious toxicity and side effects, which seriously affect the clinical efficacy. It is still an important topic to continue researching and developing new anticancer drugs with high efficiency and low toxicity. Geckos belong to the genus Gecko of the family Lizardidae, reptiles, phylum lizards, also known as Tianlong, Shougong, etc. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/48A61K35/583A61P35/00
Inventor 张仕状康建功段全红
Owner 张仕状
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