Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Carmustine precursor liposome powder injection formulation and process for preparing

A technology of precursor lipid and carmustine, which is applied in liposome delivery, amide active ingredients, drug combination, etc., can solve the problems of affecting clinical treatment effect, reducing the immune function of the body, and patients can not continue to use drugs, etc., to achieve Avoid chronic decomposition, improve therapeutic effect, effect of small particle size

Inactive Publication Date: 2004-08-18
谷松兰 +4
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has a good curative effect on malignant brain tumors, brain and spinal cord metastasis of malignant tumors, and leukemia with invasion of the central nervous system. The bone marrow hematopoietic system inhibits the regeneration of white blood cells and platelets, and reduces the immune function of the body, so that patients cannot continue to take medication and affect the clinical treatment effect
Carmustine aqueous injection is easy to decompose and has poor stability in long-term storage

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] Weigh 1.5 grams of carmustine, 4.5 grams of lecithin and 0.8 grams of cholesterol and dissolve them in ether, place for 1 hour, filter with a 0.22F type mixed fiber membrane, and add the filtrate to 20 grams of mannitol as a support agent in two times, Shake and shake to mix evenly, vacuum dry to recover ether, the vacuum degree is -0.08Mpa, then put the solid in a vacuum desiccator and vacuum dry for 20 hours to obtain loose light yellow carmustine powder injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The precursor liposome powder for injection preparation has Carmustine in 3-12 wt% as main material and other components including phospholipid 19-25 wt%, sterol 3.5-6.5 wt% and support agent 54-73 wt%. Carmustine, phospholipid and sterol are compounded into solution; the solution is added into the support agent powder gradually and the mixture is vacuum dried to form Carmustine powder for injection preparation. Before use, the Carmustine powder for injection preparation is mixed with water for injection to form Carmustine liposome injection preparation. The injection preparation has Carmustine coated in double-layer liposome film of phospholipid and sterol and thus less toxic side effect of Carmustine to human body, so that it may be used continuously for raised cancer treating effect.

Description

Technical field [0001] The invention relates to the preparation of carmustine proliposome powder injection preparation. Carmustine (Carmustine C 5 h 9 o 2 N 2 Cl 2 ) as the main raw material and formulated into proliposome powder injection. Background technique [0002] Carmustine (Carmustine) injection (carmustine injection) recorded on page 127 of the Chinese Pharmacopoeia is a sterile polyethylene glycol 400 solution of carmustine, wherein the labeled amount of carmustine is 90.0-110.0 %, the drug has high ester solubility and is easy to pass through the blood-brain barrier. It has a good curative effect on malignant brain tumors, brain and spinal cord metastasis of malignant tumors, and leukemia with invasion of the central nervous system. The bone marrow hematopoietic system inhibits the regeneration of white blood cells and platelets and reduces the immune function of the body, thus making it impossible for patients to continue taking medication and affecting th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/127A61K31/17A61P35/00
Inventor 谷松兰李玉英邓皓云沈志林黄瑞川
Owner 谷松兰
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com