Composite mineral salf of potassium-magnesium hydrogen citrate and its prepn process

A technology of potassium magnesium hydrogen citrate and compound mineral salts, which is applied in the field of compound mineral salts, can solve the problem of lack of effective drugs for urinary stones, and achieve the effect of inhibiting the formation of stones and reducing the concentration

Inactive Publication Date: 2004-04-07
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, clinically, there is a lack of effective drugs for the treatment of urinary calculi.

Method used

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  • Composite mineral salf of potassium-magnesium hydrogen citrate and its prepn process
  • Composite mineral salf of potassium-magnesium hydrogen citrate and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Mix 120g of citric acid and 30g of water in a tank, stir quickly, add 12.6g of magnesium oxide, and pass in CO 2 In the case of 64.8g of potassium carbonate, add 64.8g of potassium carbonate in four equal parts, and finally add 10g of water to complete the reaction; the reaction temperature is controlled below 100°C, and the product is prone to degradation if it exceeds 120°C, and the most suitable temperature is controlled at 80°C; after drying , the measured density is greater than 1.1g / mm 3 , can be made into tablets. Each tablet contains 1.75mmol magnesium, 5.25mmol potassium and 3.5mmol citric acid.

Embodiment 2

[0018] 48.03kg of citric acid and 12kg of water were mixed for about 2 minutes in a ribbon-shaped mixing container of 7 gallons, and then 5.04kg of MgO was added in three equal parts (every part was continuously stirred for 3 minutes), and the temperature control was then the same as in Example 1; Will 51.8kgK 2 CO 3 Divide into three parts (each part is continuously stirred for 5 minutes) and add; finally add 4kg of water, mix for 2 to 5 minutes, filter the product, and dry at 60°C for 3 hours to obtain a product (granule) with a density greater than 1.1g / mm 3 . Crush to pharmaceutical grade for pharmaceutical use.

[0019] The dried potassium magnesium hydrogen citrate is mixed with 1% (by weight) magnesium stearate, and compressed into tablets several times; each tablet contains 42mg of magnesium, 205.5mg of potassium and 662mg of citric acid.

Embodiment 3

[0021] with MgCO 3 Instead of MgO, the density is greater than 1.0g / mm 3 potassium magnesium hydrogen citrate.

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Abstract

The present invention relates to composite mineral salt of potassium-magnesium hydrogen citrate and its preparation process. The potassium-magnesium hydrogen citrate is prepared through mixing citric acid and water, and reaction with potassium compound and magnesium compound at the temperature below 100 deg.c with the molar ratio between Mg, K, H and citric acid being 1 to 3 to 1 to 2. The composite salt of potassium-magnesium hydrogen citrate has obvious curative effect on urinary calculus, owing to the citrate radical ion and magnesium ion to suppress calcium-containing calculus crystallization, magenesium ion to lower the concentration of calculus forming matter in urine and capable of combining with oxalic acid to form magnesium oxalate to exhaust together with urine. The composite salt can raise pH value of urine and dissolve uric acid calculus and cystine calculus directly without causing adverse reaction.

Description

technical field [0001] The invention relates to a composite mineral salt, in particular to a potassium-magnesium hydrogen citrate composite mineral salt and a preparation method thereof. Background technique [0002] Before the present invention was made, the medicine for clinically treating urolithiasis mainly contained potassium citrate and Paishi Granules. Patients who use potassium citrate can easily cause hyperkalemia, and the curative effect is not comprehensive; strictly speaking, Paishi Granules cannot dissolve stones, and the Akebia component in it contains nephrotoxic aristolochic acid, which is harmful to the renal tubules. Greater hazard. The crowd prevalence rate of urolithiasis can reach 5%, and the recurrence rate is also very high, 15% in one year and 50% in ten years. The main consequences of urolithiasis are hydronephrosis and urinary tract infection, which may eventually lead to Kidney impairment. Therefore, there is a lack of effective drugs for the tr...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61P13/04C07C51/41C07C59/265
Inventor 孙西钊葛卫红范明福李晖
Owner NANJING DRUM TOWER HOSPITAL
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