Ground substance and plaster of Chinese traditional medicine as well as its preparing method

Abstract

A matrix for Chinese-medicinal plaster is prepared from polyisobutylene, viscosity increaser, softening agent, filler, percutaneous absorption promoter, and solvent. Its advantages are low hypersensitivity and irritation to skin, and controllable viscosity. Its Chinese-medicinal plaster is prepared through proportionally mixing said matrix with the Chinese-medicinal extract.

Description

(1) Technical field: [0001] The invention relates to a plaster base, in particular to a traditional Chinese medicine plaster base. The invention also relates to a traditional Chinese medicine plaster using the above base and a preparation method thereof. (two) background technology: [0002] Plaster therapy is one of the five traditional dosage forms in my country. Due to the limitation of the matrix (carrier), it stays in the traditional black plaster stage for a long time. Because the black plaster contains lead and often needs to be preheated and softened, it is inconvenient to use and easily pollutes the skin. And clothing, has been gradually replaced by rubber matrix. Traditional Chinese medicine adhesive plaster overcomes the shortcomings of traditional black plasters such as inconvenient use and easy contamination of clothes. However, adhesive plasters are prone to peeling reactions, allergic reactions, irritation reactions and other adverse drug behaviors, and the sui...

AI Technical Summary

Problems solved by technology

[0012] However, the main ingredients of existing plasters that use polyisobutylene as the matrix are western medicines with a daily dose of milligrams. Since the polyisobutylene matrix has been unable to solve the problem of the small capacity of traditional Chinese medicine, if too much medicine is added to the matrix, the matrix will Other indicators, such as initial viscosity, persistent viscosity, cohesive strength, etc. will not meet the requirements, so it has not been able to be used in traditional Chinese medicine plasters

Although the application number is 96104657.0, the Chinese patent titled "A High-efficiency and Quick-acting Anti-Angina Pectoris Chinese Medicine Transdermal Sustained Release Film and Its Preparation" discloses a Chinese patent that contains polyisobutylene, azone, liquid paraffin and volatile oil extracted from traditional Chinese medicine. The application number is 9600941.5, and the patent titled "Membrane Controlled Release Scopolamine Patch" discloses a traditional Chinese medicine patch in which polyisobutylene, liquid paraffin are dissolved in chloroform and mixed with scopolamine as the reservoir layer, but the above two patents include On the storage layer with traditional Chinese medicine layer, another layer of adhesive layer needs to be set to ensure the sticking performance of the plaster, and the traditional Chinese medicine ingredients contained in it are volatile oils or alkaloids, and the amount of medicine is very small, and even if it contains Chinese medicine A small amount of volatile oil or alkaloid still cannot guarantee that it has good paste performance, and can only be used as a reservoir layer, so the above formula cannot provide a Chinese medicine plaster base that can accommodate a sufficient amount of Chinese medicine extract