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Eye cyclosporin gel

An ophthalmic gel, cyclosporine technology, applied in the directions of cyclic peptide components, sensory diseases, pharmaceutical formulations, etc., can solve the problems of easy dilution of eye drops by tears, short residence time, and difficulty in passing oral drugs through the blood-eye barrier, etc. To achieve the effect of reducing gastrointestinal irritation, long residence time, and reducing other side effects

Inactive Publication Date: 2003-11-19
刘继东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the large amount of administration and the difficulty of oral drugs passing through the blood-ocular barrier, an ophthalmic gel was invented for topical administration in ophthalmology. Small amount, improve the bioavailability of the active ingredients of the drug, increase the curative effect and drug safety

Method used

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  • Eye cyclosporin gel
  • Eye cyclosporin gel

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Experimental program
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Embodiment Construction

[0008] Prescription 1: Cyclosporin 2.0g

[0009] Carbomer 0.4g

[0010] Borax 1.0g

[0011] Boric acid 0.5g

[0012] Chlorobutanol 0.3g

[0013] Make 100.0g operation process:

[0014] ②. Add borax and boric acid to ① to make a transparent gel matrix.

[0015] ③. Cyclosporine is ground into fine powder, passed through a No. 9 sieve, and ground into ② in batches under heating conditions.

[0016] ④. Filter with 220-mesh sieve cloth, sterilize by autoclaving, subpackage, pack, and get ready.

[0017] Prescription 2: Cyclosporine 0.5-10.0g

[0018] Carbomer 0-4.0g

[0019] Borax 0-10.0g

[0020] Boric acid 0-5.0g

[0021] Chlorobutanol 0-3.0g

[0022] Make 100.0g operation process:

[0023] ①.Appropriate amount of water, dissolve chlorobutanol, add carbomer to dissolve, overnight.

[0024] ②. Add borax and boric acid to ① to make a transparent gel matrix.

[0025] ③. Cyclosporine is ground into fin...

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Abstract

A cyclosporin eye gel for treating the rejection reaction of corneal transplantation, keratoconjunctival xerosis, catarrhal conjunctivitis, and chemical burn of eye is prepared from cyclosporin, boric acid, borax, trichloro-tert-butanol, etc. Its advantages are long stay time in eye and high curative effect.

Description

Technical field [0001] The present invention relates to an active ingredient of medicine—cyclosporine—made into ophthalmic gel for the first time, which is applied to the treatment of eye diseases, and mainly treats the following eye diseases: 1. Corneal transplantation rejection, 2. Corneal and conjunctival dryness Syndrome (KC), 3, vernal catarrhal conjunctivitis, 4, ocular chemical burns (2 degrees to 4 degrees). Background technique [0002] At present, cyclosporine ophthalmic preparations are widely used in hospitals at home and abroad, all of which are hospital preparations, and no products have been listed. Phase III clinical trials are underway in the United States, and eye drops have been declared in China. There is no application for cyclosporine ophthalmic gel at home and abroad. Contents of the invention [0003] In order to overcome the large amount of administration and the difficulty of oral drugs passing through the blood-ocular barrier, an ophthalmic gel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/13A61P27/02
Inventor 刘继东姚东民高峨宋长海
Owner 刘继东
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