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Medicine prepn for treating gastrointestial tract reaction caused by chemotherapy

A pharmaceutical preparation and gastrointestinal technology, applied in the field of chemical drugs, can solve the problems of affecting the effect of treatment, treatment fear, resistance, poor antiemetic effect, etc., and achieve the effect of convenient administration route, convenient use, and reduced dosage

Inactive Publication Date: 2003-08-20
GUANGZHOU ZHONGDA XINYUAN LIFE SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] (1) It is inconvenient to use, especially the use of injections brings inconvenience to many patients
For many patients, especially children, they even have fear and resistance to treatment, which greatly affects the effect of treatment.
[0005] (2) After medication, there are many clinical adverse reactions, mainly fatigue, dizziness, headache, constipation, dry stool, abdominal pain, allergies, etc.
Although these adverse reactions are milder than the side effects of chemotherapy, they have a great inhibitory effect on the active treatment of patients
[0006] (3) The hysteresis of medication is often to wait for the patient to vomit before taking medication, and the immediate antiemetic effect is poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Tropisetron, tropisetron hydrochloride, and tropisetron mesylate are prepared into nasal drops, sprays, and powders respectively, so that each milliliter of liquid contains about 2 mg of medicine or each gram of solid powder contains about 100 mg of the drug.

[0024] Preparation method: (prepared under the environment of avoiding bacteria)

[0025] Nasal drops and sprays: Add 200 mg of tropisetron (tropisetron mesylate or tropisetron hydrochloride) to 98 ml of ethanol, add 2 ml of Tween-80, adjust the pH to 6.3~7.

[0026] Powder: Take 100 mg of tropisetron (tropisetron mesylate or tropisetron hydrochloride), add 800 mg of sodium hyaluronate and 100 mg of chitosan, mix well, and pass through a 300-mesh sieve.

[0027] How to use: Spray directly into nasal cavity

[0028] Dosage: 2 to 3 times a day, stop using when nausea and vomiting symptoms disappear

Embodiment 2

[0030] The nasal drops, sprays, and powders of the present invention are equivalent to the original tablets and injections in the treatment of gastrointestinal reactions caused by chemotherapy. This embodiment provides a comparison of the degree of adverse reactions caused by the above dosage forms during treatment. , the results are shown in Table 1.

[0031] Among them, ① represents nasal drops; ② represents spray; ③ represents powder; ④ represents tablet; ⑤ represents injection.

[0032] Table 1 preparation of the present invention and the comparison of existing dosage form adverse reaction degree after medication

[0033] Drug Adverse reaction (example)

[0034] Constipation, dry stool Abdominal pain Dry mouth Allergies

[0035] Treatment 1 day / 5 days Treatment 1 day / 5 days Treatment 1 day / 5 days Treatment 1 day / 5 days

[0036] Tropisetron① 18 / 19 13 / 14 7 / 10 8 / 10

[0037] Tropisetron② 15 / 20 12 / 10 5 / 5 2 / 1

[0038] Tropisetron③ 20 / 22 21 / 21 13 / 15 11 / 10...

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PUM

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Abstract

The medicine preparation for treating gastrointestinal tract reaction caused by chemotherapy contains the main components Troposetron, Troposetron methanesulfonate or Troposetron hydrochloride. It is prepared into nasal cavity administrated preparation, including nose drop, nose spray or nasal powder. The present invention is convenient in use and has small dosage and lessnegative reaction.

Description

technical field [0001] The invention belongs to the field of chemical medicine, and more specifically relates to a pharmaceutical preparation for treating gastrointestinal reactions caused by chemotherapy. Background technique [0002] Chemotherapy plays an increasingly important role in the treatment of malignant tumors, especially in the treatment of children. Chemotherapy has been able to cure some patients, but chemotherapy often causes gastrointestinal reactions, and patients often have symptoms of nausea and vomiting. Tropisetron (Oubiting) is a new 5-hydroxytryptamine (5-HT) receptor antagonist, which can inhibit the nausea and vomiting caused by chemotherapy in tumor patients. In addition, tropisetron mesylate and tropisetron hydrochloride, which are derivatives of tropisetron, also have a good therapeutic effect on the improvement of this symptom. [0003] At present, the above-mentioned compounds mainly adopt two forms of tablet and injection when used, and mainly...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P1/14A61P39/00
Inventor 胡绍铃梁东
Owner GUANGZHOU ZHONGDA XINYUAN LIFE SCI TECH
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