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Extractive preparation containing total alkali of mulberry leaves and its preparing method

A technology of extract and mulberry leaf, which is applied in the field of extract containing total alkali of mulberry leaf, can solve the problem that the content of the main component of the hypoglycemic effect has not been reported, and achieve the effect of significantly lowering blood sugar, improving glucose tolerance, and easy operation

Inactive Publication Date: 2003-07-23
HARBIN LONGSHENG BEIYAO BIOENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

N.Asano et al. studied the chemical composition of total alkaloids and the influence of monomeric fagomine insulin secretion, but the total alkaloids of mulberry leaves as an effective part, the research on its hypoglycemic effect and the content of main components in total alkaloids have not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Embodiment 1, 1 kg of dry mulberry leaf coarse powder, cross 20 mesh sieves, add 10 kg of 20% acetone aqueous solution, heat and reflux for extraction for 2 h, filter, repeat heat extraction for a total of three times, extract under reduced pressure and concentrate to a specific gravity of 1.20, add 3 kg of water to dissolve, Stand still, adjust the pH to 3~5 with hydrochloric acid, add appropriate amount of 1% chitosan, let stand for 12 hours, the supernatant night passes through column chromatography with 1kg of cation exchange resin as the carrier, elutes with 3kg of water, discards, pours out the resin, and adds alkaline solution After standing for 4 hours, the resin was extracted twice with 80% ethanol under reflux, each time for two hours, the extract was collected, concentrated under reduced pressure at a temperature lower than 60° C., and dried to obtain 4 g of high-content mulberry leaf total alkali extract ( Deoxynojirimycin content is 57%).

Embodiment 2

[0090] Add 10kg of dry mulberry leaf coarse powder, add 80kg of 20% ethanol, heat and reflux for extraction for 1.5h, filter, repeat the heat extraction for a total of three times, concentrate the extract under reduced pressure to a specific gravity of 1.15, add 40kg of water to dissolve, and adjust the pH to 3-5 with 10% hydrochloric acid. Add an appropriate amount of 1% chitosan, let it stand for 12 hours, the supernatant passes through the column chromatography of the cation exchange resin 10kg as the carrier, elutes with 30kg of water, discards, and the supernatant passes through the column chromatography of the ion exchange resin as the carrier, and elutes with water to It is colorless, pour out the resin, add alkali solution and let it sit for 4 hours, then reflux the resin with hydrophilic solvent methanol and extract twice, each time for 2 hours, and collect the extract. After concentrating under reduced pressure and drying at a temperature lower than 60° C., 37 g of hi...

Embodiment 3

[0092] Dried mulberry leaf coarse powder 100kg, add water 1000kg, extract under reflux for 2 hours, filter, repeat heat extraction for a total of three times, extract under reduced pressure and concentrate to specific gravity 1.2, add water 2500kg to dissolve, adjust pH3~5 with 10% hydrochloric acid, add appropriate amount of 1% Chitosan, let it stand for 12 hours, the supernatant night passes through D001 type cation exchange resin 1000kg as the carrier column chromatography, elutes with 3000kg of water, pours out the resin, adds alkali solution and leaves it for 4 hours, then extracts the resin with a hydrophilic solvent methanol reflux 2 times, each 2h, collect the extract. After concentrating under reduced pressure and drying at a temperature lower than 60°C, 320 g of high-content mulberry leaf total alkali extract (52% deoxynojirimycin content) was obtained. Example 4

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PUM

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Abstract

A medicine for reducing blood sugar and improving sugar tolerance contains mulberry leaf base (not less than 70%) and deoxynojirimycin (not less than 50%).

Description

technical field [0001] The invention relates to a mulberry leaf total alkali extract, a preparation containing it and a preparation method thereof. The preparation has obvious functions of lowering blood sugar and improving glucose tolerance. Background technique [0002] Mulberry leaves are the dry leaves of Moraceae plant Morus alba L. Mulberry leaf is a commonly used Chinese herbal medicine, which has the functions of dispelling wind-heat, clearing lung and moistening dryness, clearing liver and improving eyesight. Medical scientists at home and abroad have done a lot of research work on mulberry leaves, and found that the chemical components in mulberry leaves mainly contain flavonoids, sterols, polyhydroxyalkaloids, and polysaccharides. The crude extract of mulberry leaves, mulberry leaf sterols (ketones), mulberry leaf polysaccharides and polyhydroxyalkaloids respectively exhibit hypoglycemic activity, and there are some reports at home and abroad on the research of m...

Claims

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Application Information

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IPC IPC(8): A61K31/695A61K31/7052A61P3/10
Inventor 洪春力
Owner HARBIN LONGSHENG BEIYAO BIOENG CO LTD
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