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Tablet disintegzated in mouth rapidly for preventing and curing vomit and preparing method

A technology of disintegrating tablets and disintegrants, which is applied in the field of oral rapidly disintegrating tablets and its preparation, which can solve the problems of gritty feeling, discomfort, pasty feeling, etc., and achieve the goal of avoiding pain, nausea and vomiting, and adverse reactions Effect

Inactive Publication Date: 2003-07-23
刘智
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also some orally disintegrating tablets cause a gritty and mushy feeling and an unacceptably uncomfortable sensation when ingested

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Product Name: Granisetron Hydrochloride Orally Disintegrating Tablets

[0051] Specification: 1mg / tablet (calculated as granisetron)

[0052] Formula 1: granisetron hydrochloride 1g (calculated as granisetron)

[0053] Lactose 65g

[0054] Cross-linked polyvinylpyrrolidone (CPVP) 4g

[0055] Citric acid 0.5g

[0056] Magnesium stearate 0.5g

[0057] Mix granisetron hydrochloride, lactose, cross-linked polyvinylpyrrolidone and citric acid evenly, make 20-mesh granules by wet method with water, dry at 60°C for 4 hours, mix the dried granules with lubricant magnesium stearate evenly, Pass through an 18-mesh sieve for granulation, use a rotary conventional tablet press with a circular die, with a diameter of 5.5-6.5mm, and press 1000 tablets to obtain the finished product.

[0058] The tablet measured by the hardness tester is 2.5-3.5kg / cm 2 (n=10), and the disintegration time in the oral cavity of volunteers was 13.5 seconds (n=6). In add...

Embodiment 2

[0061] Product Name: Granisetron Hydrochloride Orally Disintegrating Tablets

[0062] Specification: 1mg / tablet (calculated as granisetron)

[0063] Formula 2: granisetron hydrochloride 1g (calculated as granisetron)

[0064] Mannitol 80g

[0065] Croscarmellose Sodium 10g

[0066] Tartaric acid 0.2g

[0067] Stevioside 1g

[0068] 5% polyvinylpyrrolidone ethanol solution appropriate amount

[0069] Magnesium stearate 0.5g

[0070] First, a certain amount of polyvinylpyrrolidone is weighed and dissolved with 30-90% ethanol to form a 5% (weight / volume, W / V) concentration of polyvinylpyrrolidone ethanol solution. Then measure an appropriate amount of the solution, add granisetron hydrochloride, stir to dissolve all the medicine in the polyvinylpyrrolidone ethanol solution, add tartaric acid and stevioside, and stir to dissolve into a clear solution. Then mix mannitol and croscarmellose sodium evenly, pass through a 120-mesh sieve ...

Embodiment 3

[0073] Product Name: Granisetron Hydrochloride Orally Disintegrating Tablets

[0074] Specification: 1mg / tablet (Granisetron Tablets)

[0075] Formula 3: granisetron hydrochloride 1g (calculated as granisetron)

[0076] Mannitol 150g

[0077] Cross-linked polyvinylpyrrolidone (CPVP) 6g

[0078] Croscarmellose Sodium 8g

[0079] Citric acid 0.3g

[0080] Aspartame 0.2g

[0081] 5% polyvinylpyrrolidone ethanol solution appropriate amount

[0082]Magnesium Stearate 1g

[0083] The preparation method and detection method of embodiment 3 and embodiment 2 are the same. Tablets measured by hardness tester are 2.5-3kg / cm 2 (n=10), and the disintegration time in the oral cavity was 10 seconds (n=6). The disintegration time detected by the method for measuring the disintegration time limit in Example 1 was 11.5 seconds (n=6).

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PUM

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Abstract

A high-speed oral disintegrant tablet for preventing the emesia caused by radiotherapy or chemicotherapy is prepared from souring agent, excipient, disintegrant or adhesive, and flavouring. Its advantages are high disintegrating speed without water (30 seconds) and high curative effect.

Description

technical field [0001] The invention relates to pharmaceutical preparations in the field of medicine, in particular to an orally rapidly disintegrating tablet for preventing and treating radiotherapy and chemotherapy emesis and a preparation method thereof. technical background [0002] "Cancer", that is, malignant tumors of organs or tissues, has become the number one killer that threatens people's health or life. Nowadays, "radiotherapy and chemotherapy" methods are often used clinically to kill tumor cells, but often patients will cause nausea and vomiting during radiotherapy and chemotherapy, which is commonly referred to as radiotherapy and chemotherapy vomiting. Vomiting is a serious side effect of radiotherapy and chemotherapy. Patients are very painful and often unbearable. Some patients even give up the treatment of the disease. Now there is a new type of antiemetic drug named "Granisetron (marketed product is granisetron hydrochloride)" listed, it is 5-hydroxytryp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/08
Inventor 刘智
Owner 刘智
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